72594-82-2Relevant academic research and scientific papers
DIAMINO ACID DERIVATIVES AS ANTIHYPERTENSIVES
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, (2008/06/13)
Novel diamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of the formula STR1 wherein: Z is amino, lower alkylamino, di-(lower alkyl)amino R 9 C(O) NH--or an optionally substituted guanidino group;R 1 is hydrogen or R. sup.7 R 8 N--;R 2 is hydrogen, lower alkyl, cyclolower alkyl, aryllower alkyl or heteroaryllower alkyl; and R 3 is hydrogen, lower alkyl or cyclolower alkyl; or R 2 and R 3, together with the carbon to which they are attached, comprise a 3-7 membered carboxyclic ring;R. sup.4 is hydrogen, lower alkyl, aryl lower alkyl or heteroaryllower alkyl; R 5 and R 6 are independently hydroxy, lower alkoxy, amino, aryllower alkoxy, lower alkylamino and di-(lower alkyl) amino;R 7 is R 9 C(O)--or R 10 SO. sub.2--; and R 8 is hydrogen, lower alkyl, aryllower alkyl or aryl; or R. sup. 7 and R 8, together with the nitrogen to which they are attached, comprise a 5-7 membered ring;R 9 is lower alkyl, aryllower alkyl, aryl, heteroaryllower alkyl, heteroaryl, lower alkoxy, aryllower alkoxy, amino, alkylamino or dialkylamino;R. sup.10 is lower alkyl, aryl lower alkyl, aryl, heteroaryl lower alkyl, amino, lower alkylamino, di-(lower alkyl)amino or heteroaryl;n is 1, 2, 3, 4 or 5; and m is 1, 2, 3, 4 or 5;or a pharmaceutically acceptable addition salt thereof, useful in the treatment of cardiovascular disorders, are disclosed.
