65621-26-3

Usage

Uses

N-alpha,beta-bis-Z-L-2,3-Diaminopropionic Acid

Upstream product

• 35761-26-3 (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid 
• 501-53-1 benzyl chloroformate 
• 60-29-7 diethyl ether 
• 515-94-6 (S)-2,3-diaminopropionic acid 
• 1186-65-8 L-2,3-diaminopropionic acid hydrobromide 

Downstream Products

• 103691-93-6 N-(L-2.3-bis-benzyloxycarbonylamino-propionyl)-glycine ethyl ester 
• 71749-02-5 N^β-Z-Dap-OMe*HCl 
• 65710-57-8 3-{[(benzyloxy)carbonyl]amino}-N-(tert-butoxycarbonyl)-L-alanine 
• 61040-22-0 N^β-benzyloxycarbonyl-N^α-Boc-(S)-β-aminoalanine methyl ester 
• 899436-88-5 C₂₁H₂₀N₂O₆ 
• 119140-68-0 (S)-2-{(S)-2-[2-(2,3-Bis-benzyloxycarbonylamino-propionylamino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester 
• 72594-82-2 4(S)-benzyloxycarbonylaminomethyl-2,5-oxazolidinedione 

Relevant academic research and scientific papers

Synthesis of (R)- and (S)-2,3-diaminopropyl sulfate: Mechanism based inhibition of glutamate 1-semialdehyde aminomutase

A short synthesis of each enantiomer of 2,3-diaminopropyl hydrogensulfate is described starting from (2R)- and (2S)-asparagine. The compounds serve as inhibitors for pyridoxal 5'-phosphate-dependent (2S)- glutamate 1-semialdehyde aminotransferase, a target for selective herbicides and antibacterial agents on the tetrapyrrole biosynthetic pathway. The (2R)- enantiomer, as predicted, serves as a potent irreversible inactivator. (C) 2000 Elsevier Science Ltd.

DIAMINO ACID DERIVATIVES AS ANTIHYPERTENSIVES

Novel diamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of the formula STR1 wherein: Z is amino, lower alkylamino, di-(lower alkyl)amino R 9 C(O) NH--or an optionally substituted guanidino group;R 1 is hydrogen or R. sup.7 R 8 N--;R 2 is hydrogen, lower alkyl, cyclolower alkyl, aryllower alkyl or heteroaryllower alkyl; and R 3 is hydrogen, lower alkyl or cyclolower alkyl; or R 2 and R 3, together with the carbon to which they are attached, comprise a 3-7 membered carboxyclic ring;R. sup.4 is hydrogen, lower alkyl, aryl lower alkyl or heteroaryllower alkyl; R 5 and R 6 are independently hydroxy, lower alkoxy, amino, aryllower alkoxy, lower alkylamino and di-(lower alkyl) amino;R 7 is R 9 C(O)--or R 10 SO. sub.2--; and R 8 is hydrogen, lower alkyl, aryllower alkyl or aryl; or R. sup. 7 and R 8, together with the nitrogen to which they are attached, comprise a 5-7 membered ring;R 9 is lower alkyl, aryllower alkyl, aryl, heteroaryllower alkyl, heteroaryl, lower alkoxy, aryllower alkoxy, amino, alkylamino or dialkylamino;R. sup.10 is lower alkyl, aryl lower alkyl, aryl, heteroaryl lower alkyl, amino, lower alkylamino, di-(lower alkyl)amino or heteroaryl;n is 1, 2, 3, 4 or 5; and m is 1, 2, 3, 4 or 5;or a pharmaceutically acceptable addition salt thereof, useful in the treatment of cardiovascular disorders, are disclosed.

AMIDE BOND ISOSTERES: IMIDAZOLINES IN PSEUDOPEPTIDE CHEMISTRY

The 2-imidazole ring has been incorporated as an amide bond replacement into pseudodipeptides, a pseudotripeptide, and pseudopentapeptide enkephalin analogues.