6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.
72596-74-8
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Basic information
- Product Name: 6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
- Synonyms: 6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE;PD 404,182;3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
- CAS NO:72596-74-8
- Molecular Formula: C11H11N3S
- Molecular Weight: 217.29
- EINECS: N/A
- Product Categories: N/A
- Mol File: 72596-74-8.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /powder
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: DMSO: ≥22 mg/mL, soluble
- CAS DataBase Reference: 6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE(CAS DataBase Reference)
- NIST Chemistry Reference: 6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE(72596-74-8)
- EPA Substance Registry System: 6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE(72596-74-8)
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Safety Data
- Hazard Codes: Xi
- Statements: 36/37/38
- Safety Statements: 26-36
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 72596-74-8(Hazardous Substances Data)
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72596-74-8 Usage
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PD 404182 is an inhibitor of SARS-CoV-2Enzyme inhibitor
This KDO-8-P synthase inhibitor and potential antibiotic (FW = 217.29 g/mol), also named 6H-6-imino(2,3,4,5-tetrahydropyrimido)[1,2-c][1,3] benzothiazine, is a slow, tight-binding agent that targets 3-deoxy-D-mannooctulosonate-8-phosphate synthase, an enzyme participating in the synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO). The latter is an essential component of LPS (lipopolysaccharide) in the outer membrane of Gramnegative bacteria. PD 404182 is an antiretroviral agent with submicromolarinhibitory activity against human immunodeficiency virus-1 (HIV-1) and HIV-2 infection. PD-404182 also potently inhibits dimethylarginine dimethylaminohydrolase isoform-1 (DDAH1), the human enzyme that degrades Asymmetric Dimethylarginine, or ADMA (See Asymmetric Dimethylarginine). Because ADMA inhibits nitric oxide synthesis and because ADMA levels are predictive for future cardiovascular disease, chronic use of PD-404182 is apt to have side-effects.Check Digit Verification of cas no
The CAS Registry Mumber 72596-74-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,5,9 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.Calculate Digit Verification of CAS Registry Number 72596-74:
(7*7)+(6*2)+(5*5)+(4*9)+(3*6)+(2*7)+(1*4)=158
158 % 10 = 8
So 72596-74-8 is a valid CAS Registry Number.
72596-74-8 Well-known Company Product Price
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Sigma
(P2742) PD 404,182 ≥98% (HPLC)
72596-74-8
P2742-2MG
1,115.01CNY
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6H-6-IMINO-(2,3,4,5-TETRAHYDROPYRIMIDO)[1,2-C]-[1,3]BENZOTHIAZINE
