726-97-6

Upstream product

• 943067-65-0 1-(3-Phenyl-ureido)-cyclohexanecarboxylic acid 
• 4896-09-7 1-(3-Phenyl-ureido)-cyclohexanecarboxylic acid ethyl ester 
• 2756-85-6 1-aminocyclohexane carboxylic acid 
• 63203-48-5 1-amino-cyclohexanecarboxylic acid ethyl ester hydrochloride 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 133466-20-3 N₃-phenyl-4-hydroxycyclohexanespiro-2-imidazolidinone 

Relevant academic research and scientific papers

Synthesis, selective aldose reductase inhibitory profile and antihyperglycaemic potential of certain parabanic acid derivatives

Synthesis and aldose reductase inhibitory profile of certain parabanic acid derivatives 1a-p is described. Also, the antihyperglycaemic potential of these compounds was studied. The most active inhibitors in this series were compounds 1 g, 1p, and 1o which showed inhibitory activity, 36.6, 90 and 91% respectively, at concentration 1 × 10-4. Their IC50 were 2 × 10-6, 7.5 × 10-8 and 5 × 10-8, respectively. Compound 1o exhibited pronounced antihyperglycaemic effect.

N3-arylspiroimidazolidine-2,4-diones N3-arylspiroimidazolidine-2-thio-4-ones and 4-hydroxy derivatives. Synthesis and anthelmintic activity.

The synthesis of new N3-arylciclohexanespiroimidazolidine-2,4-diones, N3-arylciclohexanespiroimidazolidine-2-tio-4-ones and the 4-hydroxy derivatives is described and their structures discussed on the basis of I.R. and 1H-N.R.M. data. The anthelmintic activity of these compounds was tested.