63203-48-5

Basic information

• Product Name: 1-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER HCL
• Synonyms: 1-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER HCL;1-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride;Ethyl 1-aminocyclohexanecarboxylate hydrochloride;Ethyl 1-aminocyclohexanecarboxylate HCl
• CAS NO: 63203-48-5
• Molecular Formula: C₉H₁₇NO₂*ClH
• Molecular Weight: 207.7
• Product Categories: pharmacetical
• Mol File: 63203-48-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER HCL(63203-48-5)
• EPA Substance Registry System: 1-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER HCL(63203-48-5)

Safety Data

• Hazardous Substances Data: 63203-48-5(Hazardous Substances Data)

Usage

General Description

1-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride, also known as AHU-377, is a chemical compound that is commonly used in the pharmaceutical industry. It is an ester derivative of a cyclic amino acid and is typically synthesized for research and development purposes. AHU-377 has been studied for its potential applications in the treatment of cardiovascular diseases, specifically in the development of angiotensin converting enzyme (ACE) inhibitors. The compound has shown promise in clinical studies and is being explored for its therapeutic effects on hypertension and heart failure. Its chemical structure and properties make it a valuable candidate for further investigation and potential drug development.

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 64-17-5 ethanol 
• 2756-85-6 1-aminocyclohexane carboxylic acid 

Downstream Products

• 467443-08-9 1-[3-(4-chloro-phenyl)-ureido]-cyclohexanecarboxylic acid ethyl ester 
• 4896-09-7 1-(3-Phenyl-ureido)-cyclohexanecarboxylic acid ethyl ester 
• 1612148-62-5 1-({[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylic acid 
• 1430753-58-4 ethyl 1-morpholinocyclohexanecarboxylate 
• 894-23-5 3-(4-methoxy-phenyl)-1,3-diaza-spiro[4.5]decane-2,4-dione 
• 274685-72-2 1-[N-(morpholine-4-carbonyl)amino]cyclohexane-carboxylic Acid 
• 467443-07-8 1-(2,4,5-trioxo-imidazolidin-1-yl)cyclohexanecarboxylic acid ethyl ester 
• 467443-14-7 3-(4-chlorophenyl)-1,3-diazaspiro[4.5]decane-2,4-dione 
• 730-95-0 3-benzyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 726-97-6 N₃-phenylcyclohexanespiro-2,4-imidazolidinedione 
• 106663-25-6 3-(4-chlorobenzyl)-1,3-diazaspiro[4.5]decane-2,4-dione 
• 702-62-5 spiro(imidazolidine-4,1'-cyclohexane)-2,5-dione 
• 5046-73-1 1-Ureido-cyclohexanecarboxylic acid ethyl ester 
• 467443-12-5 1-[3-(4-chloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester 

Relevant articles and documents

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Compounds of Formula (I) or a salt thereof are provided: wherein R6, R7, R8, R21, X, Ar, and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.

Synthesis, selective aldose reductase inhibitory profile and antihyperglycaemic potential of certain parabanic acid derivatives

Synthesis and aldose reductase inhibitory profile of certain parabanic acid derivatives 1a-p is described. Also, the antihyperglycaemic potential of these compounds was studied. The most active inhibitors in this series were compounds 1 g, 1p, and 1o which showed inhibitory activity, 36.6, 90 and 91% respectively, at concentration 1 × 10-4. Their IC50 were 2 × 10-6, 7.5 × 10-8 and 5 × 10-8, respectively. Compound 1o exhibited pronounced antihyperglycaemic effect.