63203-48-5

Usage

Uses

Used in Pharmaceutical Industry:
1-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride is used as a research compound for the development of novel therapeutic agents. Its unique structure and properties make it a promising candidate for further investigation and potential drug development.
Used in Cardiovascular Disease Treatment:
AHU-377 is used as a potential treatment for cardiovascular diseases, specifically in the development of angiotensin-converting enzyme (ACE) inhibitors. It has shown promise in clinical studies and is being explored for its therapeutic effects on hypertension and heart failure.
Used in Angiotensin-Converting Enzyme (ACE) Inhibitor Development:
1-Amino-cyclohexanecarboxylic acid ethyl ester hydrochloride is used as a precursor in the synthesis of ACE inhibitors. These inhibitors play a crucial role in regulating blood pressure and are widely used in the treatment of hypertension and heart failure. AHU-377's potential as an ACE inhibitor makes it a valuable compound for further research and development in this area.

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 64-17-5 ethanol 
• 2756-85-6 1-aminocyclohexane carboxylic acid 

Downstream Products

• 467443-08-9 1-[3-(4-chloro-phenyl)-ureido]-cyclohexanecarboxylic acid ethyl ester 
• 4896-09-7 1-(3-Phenyl-ureido)-cyclohexanecarboxylic acid ethyl ester 
• 467443-11-4 1-(3-benzyl-ureido)-cyclohexanecarboxylic acid ethyl ester 
• 467443-12-5 1-[3-(4-chloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester 
• 5046-73-1 1-Ureido-cyclohexanecarboxylic acid ethyl ester 
• 274685-72-2 1-[N-(morpholine-4-carbonyl)amino]cyclohexane-carboxylic Acid 
• 1612148-62-5 1-({[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylic acid 
• 1430753-58-4 ethyl 1-morpholinocyclohexanecarboxylate 
• 894-23-5 3-(4-methoxy-phenyl)-1,3-diaza-spiro[4.5]decane-2,4-dione 
• 467443-07-8 1-(2,4,5-trioxo-imidazolidin-1-yl)cyclohexanecarboxylic acid ethyl ester 
• 467443-14-7 3-(4-chlorophenyl)-1,3-diazaspiro[4.5]decane-2,4-dione 
• 730-95-0 3-benzyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 726-97-6 N₃-phenylcyclohexanespiro-2,4-imidazolidinedione 
• 106663-25-6 3-(4-chlorobenzyl)-1,3-diazaspiro[4.5]decane-2,4-dione 

Relevant academic research and scientific papers

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Compounds of Formula (I) or a salt thereof are provided: wherein R6, R7, R8, R21, X, Ar, and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.

Wang-aldehyde resin as a recyclable support for the synthesis of α,α-disubstituted amino acid derivatives

Merrifield resin was functionalised with hydroxybenzaldehyde under microwave irradiation. The resultant resin was used as a means for immobilisation and activation of α-amino acid esters for alkylation reactions. α,α-Disubstituted and cyclic amino acid esters were prepared in good yields. The Royal Society of Chemistry 2005.

Synthesis, selective aldose reductase inhibitory profile and antihyperglycaemic potential of certain parabanic acid derivatives

Synthesis and aldose reductase inhibitory profile of certain parabanic acid derivatives 1a-p is described. Also, the antihyperglycaemic potential of these compounds was studied. The most active inhibitors in this series were compounds 1 g, 1p, and 1o which showed inhibitory activity, 36.6, 90 and 91% respectively, at concentration 1 × 10-4. Their IC50 were 2 × 10-6, 7.5 × 10-8 and 5 × 10-8, respectively. Compound 1o exhibited pronounced antihyperglycaemic effect.