726196-87-8

Upstream product

• 16365-27-8 2-(4-nitrophenoxy)ethanol 
• 350-46-9 4-Fluoronitrobenzene 
• 647858-20-6 4-(2-benzyloxyethoxy)-1-nitrobenzene 

Downstream Products

• 647858-22-8 [4-(2-benzyloxy-ethoxy)-phenyl]-carbamic acid benzyl ester 
• 1003884-38-5 3-[4-(2-benzyloxyethoxy)phenyl]-2-chloropropionic acid methyl ester 
• 726196-88-9 N-{4-[2-(benzyloxy)ethoxy]phenyl}-4-methoxybenzenecarboximidamide 
• 647858-26-2 N-{3-[4-(2-benzyloxy-ethoxy)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 647858-30-8 Methanesulfonic acid 2-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-phenoxy}-ethyl ester 
• 647858-24-0 (R)-3-[4-(2-Benzyloxy-ethoxy)-phenyl]-5-hydroxymethyl-oxazolidin-2-one 
• 647858-28-4 N-{3-[4-(2-hydroxy-ethoxy)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 

Relevant academic research and scientific papers

NOVEL ANTIDIABETIC COMPOUNDS

The present invention provides novel compounds of the general formula (I), wherein the symbols are same as described in specification, their pharmaceutically acceptable salts, their tautomeric forms, their stereoisomers, pharmaceutical compositions containing them, to process and intermediates for the preparation of the above said compounds, having the utility of these compounds in medicine and to methods for their therapeutic use, and their use in the treatment of diabetes and related diseases.

Influence of ethylene-oxy spacer group on the activity of linezolid: Synthesis of potent antibacterials possessing a thiocarbonyl group

The influence of an ethylene-oxy spacer element between the heterocycle and the aromatic ring in linezolid is reported. The introduction of such spacer group generated compounds with inferior antibacterial activity. However, the conversion of the acetamide group present in the linezolid analogues to either thiocarbamate or thioacetamide functionality restored the activity. The synthesis of linezolid analogues possessing the ethylene-oxy spacer group along with SAR studies with different heterocycles and preparation of some thiocarbonyl compounds possessing potent antibacterial property are presented.