72627-52-2

Upstream product

• 92232-57-0 (3S,4S,5S)-3-Benzo[1,3]dioxol-5-ylmethyl-4-(3,4,5-trimethoxy-benzyl)-5-trityloxymethyl-dihydro-furan-2-one 
• 76236-34-5 (4S,5S)-4-(3,4,5-Trimethoxy-benzyl)-5-trityloxymethyl-dihydro-furan-2-one 
• 76236-31-2 (S)-3-Phenylselanyl-5-trityloxymethyl-dihydro-furan-2-one 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 72605-53-9 γ-benzyloxymethyl-α,β-butenolide 
• 2606-51-1 3,4-Methylenedioxybenzyl bromide 
• 57009-70-8 2-(3,4,5-trimethoxyphenyl)-1,3-dithiane 
• 32780-08-8 (5S)-5-[(benzyloxy)methyl]dihydrofuran-2(3H)-one 
• 76236-31-2 (4S)-(+)-2-phenylseleno-4-trityloxymethyl-butan-4-olide 
• 73968-62-4 (5S)-5-[(trityloxy)methyl]tetrahydro-2-furanone 
• 76236-32-3 2,3-dideoxy-5-O-(triphenylmethyl)-D-glycero-pent-2-enono-1,4-lactone 
• 76236-33-4 (3S,4S)-(+)-3-(2-(3,4,5-trimethoxyphenyl)-1,3-dithiane-2-yl)-4-trityloxymethyl-butan-4-olide 
• 72605-52-8 (4S)-(+)-2-phenylseleno-4-benzyloxymethyl-butan-4-olide 

Downstream Products

• 61038-90-2 (-)-isostegane 
• 41451-68-7 (+)-episteganacin 
• 40456-50-6 yatein 
• 41451-68-7 (+)-steganacin 
• 72627-54-4 (3S,4S)-(+)-2-hydroxy-3-(3',4',5'-trimethoxybenzyl)-4-piperonyl-tetrahydrofurane 
• 41451-68-7 (+)-steganacin 
• 61038-90-2 (-)-isostegane 
• 61038-90-2 (+)-stegane 
• 72690-16-5 (3S,4S)-4-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3,4,5-trimethoxybenzyl)dihydrofuran-2(3H)-one 
• 76236-36-7 (2S,3S,4S)-(+)-3-(3',4',5'-trimethoxybenzyl)-4-piperonyl-1,2,5-pentanetriol 

Relevant academic research and scientific papers

ASYMMETRIC TOTAL SYNTHESIS OF NATURAL (-)- AND UNNATURAL (+)-STEGANACIN DETERMINATION OF THE ABSOLUTE CONFIGURATION OF NATURAL ANTITUMOR STEGANACIN

A virtually complete asymmetric control in the synthesis of 2,3-disubstituted butan-4-olide (10) was demonstrated by employing the butenolide (12) as the chiral acceptor for the conjugate 1,4-addition.Highly efficient asymmetric total synthesis of natural (-)- and unnatural (+)-steganacin was accomplished.The absolute stereostructure of natural antitumor steganacin was determined to be 1.

FIRST ASYMMETRIC TOTAL SYNTHESIS OF (+)-STEGANACIN. DETERMINATION OF ABSOLUTE STEREOCHEMISTRY

(+)-Steganacin was synthesized in a new and highly specific asymmetric pathway based on the novel application of chiral γ-lactone as a chiral synthon.By this synthesis the absolute stereochemistry of natural (-)-steganacin could be determined in unequivoc