76236-31-2

Upstream product

• 34837-55-3 Phenylselenyl bromide 
• 73968-62-4 (5S)-5-[(trityloxy)methyl]tetrahydro-2-furanone 
• 1666-13-3 diphenyl diselenide 

Downstream Products

• 76236-32-3 2,3-dideoxy-5-O-(triphenylmethyl)-D-glycero-pent-2-enono-1,4-lactone 
• 53798-51-9 Verrucarinsaeure, α,δ-Dihydroxy-β-methyl-valeriansaeure 
• 81480-31-1 (S)-(-)-4-methyl-5-trityloxymethyl-2(5H)-furanone 
• 84911-45-5 (S)-4-Methyl-5-trityloxymethyl-dihydro-furan-2-one 
• 81474-42-2 (-)-3-carboxy-4-(1-hydroxy-2-trityloxyethyl)-1-pyrazoline γ-lactone 
• 72627-52-2 (2S,3S,4S)-(+)-2-piperonyl-3-(3,4,5-trimethoxybenzyl)-4-hydroxymethyl-butan-4-olide 
• 76236-35-6 (3S,4S)-(+)-3-(3,4,5-trimethoxybenzyl)-4-hydroxymethyl-butan-4-olide 
• 76236-36-7 (2S,3S,4S)-(+)-3-(3',4',5'-trimethoxybenzyl)-4-piperonyl-1,2,5-pentanetriol 
• 76236-34-5 (4S,5S)-4-(3,4,5-Trimethoxy-benzyl)-5-trityloxymethyl-dihydro-furan-2-one 
• 76236-33-4 (3S,4S)-(+)-3-(2-(3,4,5-trimethoxyphenyl)-1,3-dithiane-2-yl)-4-trityloxymethyl-butan-4-olide 
• 92232-57-0 (3S,4S,5S)-3-Benzo[1,3]dioxol-5-ylmethyl-4-(3,4,5-trimethoxy-benzyl)-5-trityloxymethyl-dihydro-furan-2-one 

Relevant academic research and scientific papers

ASYMMETRIC TOTAL SYNTHESIS OF NATURAL (-)- AND UNNATURAL (+)-STEGANACIN DETERMINATION OF THE ABSOLUTE CONFIGURATION OF NATURAL ANTITUMOR STEGANACIN

A virtually complete asymmetric control in the synthesis of 2,3-disubstituted butan-4-olide (10) was demonstrated by employing the butenolide (12) as the chiral acceptor for the conjugate 1,4-addition.Highly efficient asymmetric total synthesis of natural (-)- and unnatural (+)-steganacin was accomplished.The absolute stereostructure of natural antitumor steganacin was determined to be 1.

SYNTHETIC APPROACHES TOWARD VERRUCARIN A. CHIRAL SYNTHESIS OF (-)-VERRUCARINOLACTONE

(-)-Verrucarinolactone ((2S,3R)-2,5-dihydroxy-3-methylvaleric acid δ-lactone) (4) was synthesized stereoselectively from an optically active butyrolactone ((S)-γ-trityloxymethyl-γ-butyrolactone) (6) as a chiral synthon.

FIRST ASYMMETRIC TOTAL SYNTHESIS OF (+)-STEGANACIN. DETERMINATION OF ABSOLUTE STEREOCHEMISTRY

(+)-Steganacin was synthesized in a new and highly specific asymmetric pathway based on the novel application of chiral γ-lactone as a chiral synthon.By this synthesis the absolute stereochemistry of natural (-)-steganacin could be determined in unequivoc