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Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-2,4-difluoro-6-methyl-pyrimidine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features allow for the development of new drugs with improved efficacy, selectivity, and reduced side effects. 5-CHLORO-2,4-DIFLUORO-6-METHYL-PYRIMIDINE's reactivity and functional group compatibility make it an attractive candidate for the design and synthesis of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 5-chloro-2,4-difluoro-6-methyl-pyrimidine is utilized as a starting material for the development of new pesticides, herbicides, and insecticides. Its structural diversity and compatibility with various functional groups enable the creation of innovative agrochemicals with enhanced performance, selectivity, and environmental compatibility.
Used in Organic Synthesis:
5-Chloro-2,4-difluoro-6-methyl-pyrimidine is employed as a versatile building block in organic synthesis, allowing for the construction of a wide range of complex organic molecules. Its unique structural features and reactivity make it an ideal candidate for the synthesis of various specialty chemicals, including dyes, polymers, and advanced materials.
Used in Research and Development:
5-CHLORO-2,4-DIFLUORO-6-METHYL-PYRIMIDINE is also used in research and development settings, where it serves as a valuable tool for understanding the structure-activity relationships of various biologically active molecules. Its unique structural features and reactivity enable researchers to explore new synthetic routes and develop innovative strategies for the design and synthesis of novel compounds with potential applications in various industries.

InChI:InChI=1/C5H3ClF2N2/c1-2-3(6)4(7)10-5(8)9-2/h1H3

Upstream product

• 6554-69-4 6-Methyl-2,4,5-trichloropyrimidine 

Relevant academic research and scientific papers

THE FLUORINATION OF 2,4,5-TRICHLORO-6-METHYLPYRIMIDINE; EXPERIMENTAL STUDY AND CNDO/2 CALCULATION

A study of the kinetics and mechanism of the fluorination of 2,4,5-trichloro-6-methylpyriimidie (TCMP) to form 2,4-difluoro-5-chloro-6-methylpyrimidine (DFCMP) in polar aprotic solvents with KF or NaF has been performed.The rate constants of the fluorination under various conditions were measured.This fluorination proceeds as a pseudo-first-order consecutive reaction.The values of the activation enthalpy ΔH*, the activation entropy ΔS* and Arrhenius activation energy ΔEa were evaluated and the influence of solvents, catalysts and fluorinating agents was discussed.The CNDO/2 method has been applied to the calculation of the reaction path of the fluorination and the energy levels of the components.The calculated results agree well with experimental observation.

FLUORINATED HETEROCYCLIC COMPOUNDS: SELECTIVE CHLORONE/FLUORINE EXCHANGE REACTIONS ON PYRIMIDINES

Selective chlorine/fluorine exchange reactions on tetrachloropyrimidine, 6-methyl-, 6-chloromethyl-, 6-dichloromethyl, and 6-trichloromethyl-2,4,5-trichloropyrimidine are described.Sodium fluoride, potassium fluoride, hydrogen fluoride, and antimony trifluoride were used as the fluorinating agents.It was found that NaF and KF fluorinate only in the heterocyclic nucleus, HF in the nucleus and in the chlorinated methyl group, and SbF3 only in the chlorinated methyl group.In the first stage of fluorination with NaF only chlorine bound in position 4 of the pyrimidine ring is exchanged.The HF reaction is an equilibrium reaction in which the substitution of the fluorine for the first chlorine atom occurs preferentially in position 2.The behaviour of partly fluorinated pyrimidines in nucleophilic exchange reactions is also discussed.