72632-66-7

Upstream product

• 23741-79-9 Isopropylmalonsauredinitril 
• 81569-57-5 4-(1-methylethyl)thiazole-5-carboxylic acid ethyl ester 
• 72850-76-1 ethyl 2-amino-4-isopropyl-1,3-thiazole-5-carboxylate 
• 35391-60-7 ethyl 2-chloro-4-methyl-3-oxopentanoate 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 

Relevant academic research and scientific papers

Synthetic method of drug intermediate sulfur-containing nitrogen heterocyclic amine compound (by machine translation)

To the invention, 4 -N-BOC -3 - isopropylthiazole is obtained by reaction of 2 - methyl -4 - oxo-pentanoic acid ethyl ester, dichloromethane and sulfonyl chloride as a raw material, and then -3 - N-BOC - 2 - isopropylthiazole and HCl are added in the presence of ethanol as a solvent to obtain -4 - N-BOC-n-isopropythiazol -5 - methyl 4 -isoprop -5 -aminothiazole in the presence of triethylamine, and a NaOH solution is added as a solvent and then subjected to extraction washing to obtain 4 -yl -5 -aminothiazolethyl acetate in the presence of trifluoroethanol as a solvent and ethanol as a solvent to obtain ethyl acetate 4 - 5-propyl thiazole -5 - formic acid ethyl ester with ethanol as a 4 - solvent and an aqueous solution of N-BOC-5 n-isopropylthiazole 4 - and the like 4 -5 . The method has the advantages of clear steps, less waste, high yield, raw material saving and easy operation. (by machine translation)