72667-91-5Relevant academic research and scientific papers
Trithioorthoesters and Tetrathioorthocarbonates as RC(3+) and C(4+) Synthons. Nickel-Catalyzed Alkylative Olefination of Trithioorthoesters and Tetrathioorthocarbonates
Tzeng, Yih-Ling,Cheng, Wen-Lung,Luh, Tien-Yau
, p. 385 - 393 (2007/10/02)
NiCl2(PPh3)2-catalyzed alkylative olefinations of trithioorthoesters and tetrathioorthocarbonates give the corresponding substituted alkenes.Aliphatic C-S bonds in these substrates can be activated in the nickel-catalyzed cross coupling reaction leading to carbon-carbon bond formation.This reaction can be considered as using trithiorthoesters and tetrathioorthocarbonate as R3C(3+) and C(4+) synthons. - Keywords: Trithioorthoesters, Tetrathioorthocarbonate, Nickel-Catalyzed Alkylative Olefination, Synthons of RC(3+) and C(4+)
Nickel-catalysed Alkylative Alkenation of Orthothioesters with Grignard Reagents; a Convenient Procedure for introducing the Isopropenyl Group. Synthesis of Substituted 1,3-(Bis-trimethylsilyl)propenes
Tzeng, Yih-Ling,Luh, Tien-Yau,Fang, Jim-Min
, p. 399 - 400 (2007/10/02)
Nickel-catalysed coupling of orthothioesters with MeMgI furnishes a general method for introducing the isopropenyl group; the application of this reaction to the synthesis of 1,3-(bis-trimethylsilyl)propenes is presented.
SUBSTITUTED 7,7',8,8'-TETRACYANOQUINODIMETHANES. I. METHODS OF SYNTHESIS OF SUBSTITUTED 7,7',8,8'-TETRACYANOQUINODIMETHANES
Russkikh, V. S.,Abashev, G. G.
, p. 742 - 745 (2007/10/02)
The synthesis of 2-methyl-, 2,5-dimethyl-, and 2-isopropyl-7,7'-8,8'-tetracyanoquinodimethanes was realized from 2-methyl-, 2,5-dimethyl-, and 2-isopropyl-1,4-cyclohexanediones.These cyclic diketones are obtained with good yields by the Birch reduction of 2-chloromethyl-, 2,5-dichloromethyl-, and 2-isopropyl-1,4-dimethoxybenzenes.
Phenylalkylamines with potential psychotherapeutic utility. 2. Nuclear substituted 2-amino-1-phenylbutanes
Standridge,Howell,Tilson,Chamberlain,Holava,Gylys,Partyka,Shulgin
, p. 154 - 162 (2007/10/02)
A series of 2-amino-1-(4-substituted-2,5-dimethoxyphenyl)butanes was prepared as analogues of (R)-2-amino-1-(2,5-dimethoxy-4-methylphenyl)butane (1a). 1-(2,5-Dimethoxyphenyl)-2-(N-phthalimido)butane (7) was utilized as a synthetic intermediate common to many of the target compounds. Animal data are presented indicating that most of these analogues have low hallucinogenic potential. Selected compounds were compared with 1a in an avoidance-response acquisition model which differentiates between 1a and the human hallucinogens DOM (2a) and DOET (2b). Structure-activity relationships of these analogues are discussed.
