726697-66-1Relevant academic research and scientific papers
Palladium-catalyzed silastannation of secondary propargylic alcohols and their derivatives
Nielsen, Thomas E.,Le Quement, Sebastian Le,Tanner, David
, p. 1381 - 1390 (2004)
A series of terminal propargylic alcohols and their derivatives were subjected to Pd-catalyzed silastannation. In all reactions, complete regio- and stereoselectivities were observed with the tributyltin moiety exclusively adding to the internal carbon of the triple bond in a cis fashion, including the first example of a diyne bis-silastannation. Silastannation reaction products could sequentially be protiodesilylated or iododestannylated, thus providing synthetic routes to 1,1-gem-disubstituted alkenylstannanes and iodides, respectively.
