72676-48-3Relevant academic research and scientific papers
Preparation of α-functionalized alkenylmagnesium reagents via a halide-magnesium exchange
Thibonnet, Jér?me,Anh Vu, Viet,Bérillon, Laurent,Knochel, Paul
, p. 4787 - 4799 (2007/10/03)
A general preparation of alkenylmagnesium derivatives bearing an electron-withdrawing function in the α-position (Y=CN, CO2R, CONR2, SO2Ph) has been made possible by using a low temperature (-40 to -30°C) bromine-magnesium exchange with i-PrMgBr in THF. This reaction has also been used to prepare 5-magnesiated-1,3-dioxin-4-one derivatives bearing an alkoxy substituent in β-position to the carbon-magnesium bond.
Stereoselective Synthesis of (E)-2-(1-Hydroxyalkyl)alk-2-enenitriles via (Z)-1-Cyanoalk-1-enyl Anion Intermediates
Sato, Yoshiro,Hitomi, Kyoko
, p. 170 - 171 (2007/10/02)
Fluoride ion-induced desilylation of (E)-2-trimethylsilylalk-2-enenitriles affords (Z)-1-cyanoalk-1-enyl anion intermediates, which are trapped by carbonyl compounds to give (E)-2-(1-hydroxyalkyl)alk-2-enenitriles with 100percent retention of the configur
