72676-70-1 Usage
General Description
1-(2-chloroethyl)-3-[4-(1-methyl-2,5-dioxopyrrolidin-3-yl)phenyl]-1-nitrosourea, also known as nimustine, is a chemotherapy drug used to treat certain types of cancer. It belongs to the class of alkylating agents, which work by damaging the DNA in cancer cells, preventing their replication and ultimately causing their death. Nimustine is specifically used for the treatment of brain tumors, including gliomas and glioblastomas, as well as certain types of lymphomas and metastatic melanoma. It is typically administered intravenously, and its use is associated with potential side effects such as bone marrow suppression, nausea, vomiting, and hair loss. Ongoing research is being conducted to explore the potential of nimustine in combination therapies for various other types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 72676-70-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,6,7 and 6 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 72676-70:
(7*7)+(6*2)+(5*6)+(4*7)+(3*6)+(2*7)+(1*0)=151
151 % 10 = 1
So 72676-70-1 is a valid CAS Registry Number.
72676-70-1Relevant articles and documents
Synthesis and Anticancer Activity of Nitrosourea Derivatives of Phensuximide
Crider, A. Michael,Kolczynski, Thomas M.,Yates, Kathleen M.
, p. 324 - 326 (2007/10/02)
Nitrosourea derivatives 9-13 which utilize phensuximide (1) as the carrier were synthesized as potential central nervous system antitumor agents.The N-(2-chloroethyl)-N-nitrosourea 13 was active in the mouse ependymoblastoma brain-tumor system, as well as
