72680-69-4

Upstream product

• 110-91-8 morpholine 
• 27200-79-9 p-bromophenylacetaldehyde 
• 20684-76-8 4-<(Diphenylphosphinoyl)methyl>morpholine 
• 1122-91-4 4-bromo-benzaldehyde 
• 16532-79-9 4-Bromophenylacetonitrile 
• 80743-28-8 1-(4-bromo-phenyl)-2-diphenylphosphinoyl-2-morpholin-4-yl-ethanol 

Downstream Products

• 168426-25-3 3,5-bis(4-bromophenyl)pyridine 
• 78077-49-3 1-[4-(4-Bromo-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-ethanone 
• 77442-93-4 [4-(4-Bromo-phenyl)-1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-acetic acid 
• 77442-92-3 4-<4-(4-Bromphenyl)-1-(4-fluorphenyl)-3-pyrazolyl-thioacetyl>morpholin 
• 371167-72-5 4-[2-(4-bromophenyl)-1-morpholinoethylideneamino]-6-methyl-2H-pyran-2-one 
• 77452-39-2 1-[4-(4-Bromo-phenyl)-1-(4-fluoro-phenyl)-5-morpholin-4-yl-4,5-dihydro-1H-pyrazol-3-yl]-ethanone 

Relevant academic research and scientific papers

NEW DERIVATIVES OF 2-PYRIDIN ACETIC ACID AS COMPOUNDS WITH ANTIPROLIFERATIVE ACTIVITY

The present invention refers to new derivatives of 2-pyridin acetic acid usefully employable as antagonists of the action of some growth factors and therefore their use as drugs active in the treatment and/or prevention of pathologies deriving from uncont

Synthesis of dicationic diarylpyridines as nucleic-acid binding agents

The syntheses of 2,6-bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]pyridine 7, 2-[4-(4,5-dihydro-1H-imidazol-2-yl)-phenyl]-6-[3-(4,5-dihydro- 1H-imidazol-2-yl)phenyl]pyridine 8 and 2,6-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]pyridine 9 in five steps from the appropriately substituted bromoacetophenone are described. 3,5-Bis[4-(4,5-dihydro-1H-imidazol-2-yl) phenyl]pyridine 13 is also reported, prepared in four steps from 4-bromophenylacetonitrile. The preparation of 2,5-bis[4-(4,5-dihydro-IH-imidazol-2-yl) phenyl]pyridine Is from 4-bromoacetophenone in six steps is presented. The dications bind to poly dA·dT in the order 7 > 13 > 18 > 8 > 9; the order of binding to poly A·U is 7 > 13 > 8 > 9; 18 essentially does not bind to the RNA model. Only 7 inhibits topoisomerase II at millimolar concentrations. The dicationic compounds that were tested against Pneumonocystis carinii in the immunosuppressed rat model show only modest activity and are moderately toxic. Some of the compounds demonstrated modest anti-HIV-1 activity and selectivity in primary lymphocytes.

Enamine synthesis using the Horner-Wittig reaction. Part 1. (Aminomethyl)diphenylphosphine oxides, new formyl anion equivalents

Using the Horner-Wittig reagent (morpholinomethyl)diphenylphosphine oxide (7), aromatic, aliphatic and α,β-unsaturated aldehydes are converted into morpholino enamines of their homologous aldehydes.With diphenylphosphine oxide (12), the same aldehydes, together with the ketones (cyclic as well as acyclic, both saturated and α,β-unsaturated), are converted into enamines of their homologous aldehydes.Both types of enamines are converted into the corresponding aldehydes by mild, acid-catalyzed hydrolysis, showing the utility of 7 and 12, as formyl anion equivalents.Preparation of each geometrical isomer of the N-methylanilino enamines is possible since the intermediate diastereoisomeric adducts 13 can be separated.