20684-76-8Relevant academic research and scientific papers
8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4-hydroxy-quinolizine-3-carboxylate and synthetic method thereof
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Paragraph 0035; 0036, (2017/08/28)
The invention provides 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4-hydroxy-quinolizine-3-carboxylate and a synthetic method thereof. The synthetic method comprises the following steps: a compound 6 and tert-butyldimethylsilyl chloride react in a firs
New ruthenium(II) coordination compounds possessing bidentate aminomethylphosphane ligands: Synthesis, characterization and preliminary biological study in vitro
P?otek, Micha?,Starosta, Rados?aw,Komarnicka, Urszula K.,Skórska-Stania, Agnieszka,Jezowska-Bojczuk, Ma?gorzata,Stochel, Grazyna,Kyzio?, Agnieszka
, p. 13969 - 13978 (2015/08/18)
Addition of aminomethylphosphane P{CH2N(CH2CH2)2O}3 (1), PPh2{CH2N(CH2CH2)2O} (2) or PPh2{CH2N(CH2CH2
Copper-catalyzed α-amination of phosphonates and phosphine oxides: A direct approach to α-amino phosphonic acids and derivatives
McDonald, Stacey L.,Wang, Qiu
supporting information, p. 1867 - 1871 (2014/03/21)
A direct approach to important α-amino phosphonic acids and its derivatives has been developed by using copper-catalyzed electrophilic amination of α-phosphonate zincates with O-acyl hydroxylamines. This amination provides the first example of C=N bond formation which directly introduces acyclic and cyclic amines to the α-position of phosphonates in one step. The reaction is readily promoted at room temperature with as little as 0.5 mol % of catalyst, and demonstrates high efficiency on a broad substrate scope. A direct approach to important α-amino phosphonic acids and derivatives, by using copper-catalyzed electrophilic amination of α-phosphonate zincates using O-acylhydroxylamines, is described. This amination is the first example of C=N bond formation which directly introduces acyclic and cyclic amines to the α-position of phosphonates in one step. The reaction proceeds at room temperature with as little as 0.5 mol % of the catalyst. Copyright
Efficient synthesis of phosphono- and phosphinoxidomethylated N-heterocycles under solvent-free microwave conditions
Prauda, Ibolya,Greiner, Istvan,Ludanyi, Krisztina,Keglevich, Gyoergy
, p. 317 - 322 (2007/10/03)
Simple N-heterocycles were converted to N-phosphono- and phosphinoxidomethyl derivatives by a solvent-free microwave-assisted condensation of the heterocycle, paraformaldehyde, and diethylphosphite or diphenylphosphine oxide in a convenient and, in most cases, efficient way. In contrast to an earlier report, imidazole proved to be unreactive in this type of phospha-Mannich reaction. Copyright Taylor & Francis Group, LLC.
A New Access to 3-(2'-Aminovinyl)indoles and Their First Diels-Alder Reactions
Pindur, Ulf,Otto, Christian
, p. 403 - 406 (2007/10/02)
3-Acylindoles react with α-amino-α'-diphenylphosphinoyl-substituted carboanions to 3-(2'-aminovinyl)indoles (7 and 12) via carbinols.The electron-rich 3-vinylindoles 7 and 12 undergo Diels-Alder reactions with N-phenylmaleimide.
A New Access to 2'-Amino-substituted Vinylindoles as Donor-activated Heterocyclic Dienes and their First Diels-Alder Reactions
Pindur, Ulf,Otto, Christian
, p. 3515 - 3526 (2007/10/02)
Reactions of the 3-acylindoles 5, 10, and 15 with α-amino-α'-diphenylphosphinoyl-substituted carbanions gave rise to the 2'-amino-substituted 3- and 2-vinylindoles 7, 12, and 17 by way of the isolable carbinols 6, 11, and 16.The heterocyclic dienes 7, 12,
Acylaminomethyl-diphenylphosphine Oxides
Moehrle, Hans,Vetter, Wolfgang
, p. 427 - 430 (2007/10/02)
Aminomethyl-diphenylphosphine oxides 3 - 7 react with mercury(II)-edta yielding the acylamino derivatives 8 - 11.The attack at a N-methyl group and the formation of the formamide 11 in high yield is surprising, the preferred rotamer of 11 is determined.
The synthesis of α-amino-substituted diphenylphosphine oxides
Broekhof, N. L. J. M.,Elburg, P. van,Gen, A. van der
, p. 312 - 316 (2007/10/02)
Four methods with differing but overlapping specificity are described for the synthesis of α-unsubstituted as well as α-substituted (aminomethyl)diphenylphosphine oxides.The first method is based on the Arbusov reaction, the second on a Mannich-type condensation of diphenylphosphine oxide with aldehydes and secondary amines, the third on the addition of Ph2P(O)H to enamines and the fourth on the reaction of anions derived from α-unsubstituted (aminomethyl)diphenylphosphine oxides with various electrophiles.
