72681-06-2

Upstream product

• 72681-05-1 (E/Z)-3-methyl-5-phenylpent-2-enoic acid 
• 36805-43-3 ethyl (E)-3-methyl-5-phenylpent-2-enoate 
• 2550-26-7 4-Phenyl-2-butanone 

Downstream Products

• 53243-60-0 3-methyl-5-phenyl-pent-2-enenitrile 
• 72680-92-3 (S)-3-methyl-5-phenylpentanamide 
• 76155-52-7 (R)-3-methyl-5-phenylpentanamide 

Relevant academic research and scientific papers

Highly efficient Rh-catalyzed asymmetric hydrogenation of α,β-unsaturated nitriles

A highly efficient enantioselective hydrogenation of α,β-unsaturated nitriles catalyzed by Rh-(R,R)-f-spiroPhos complex has been developed. With Rh-(R,R)-f-spiroPhos catalyst and under mild conditions, a wide range of α,β-unsaturated nitriles including the (E)- and (Z)-isomers of 3-alkyl-3-aryl, 3,3-diaryl, and 3,3-dialkyl α,β-unsaturated nitriles were hydrogenated to the corresponding chiral nitriles with excellent enantioselectivities (up to 99.9% ee) and high turnover numbers (TON up to 10,000).

Enantioselective Conjugate Reduction of α,β-Unsaturated Carboxamides with Semicorrin Cobalt Catalysts

Chiral semicorrin cobalt complexes, prepared in situ from cobalt(II) chloride and the free ligands, are efficient, highly enantioselective catalysts for the conjugate reduction of α,β-unsaturated carboxamides with sodium borohydride.Enantiomeric excesses of up to 99percent, essentially quantitative yields, and high substrate/catalyst ratios (1000-10 000:1) are attractive attributes of this catalytic process.