72693-02-8

Basic information

• Product Name: 2-Pyridinecarboxamide,4,6-dimethyl-(9CI)
• Synonyms: 2-Pyridinecarboxamide,4,6-dimethyl-(9CI);4,6-Dimethyl-pyridine-2-carboxylic acid amide
• CAS NO: 72693-02-8
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.1778
• Product Categories: AMIDE
• Mol File: 72693-02-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyridinecarboxamide,4,6-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide,4,6-dimethyl-(9CI)(72693-02-8)
• EPA Substance Registry System: 2-Pyridinecarboxamide,4,6-dimethyl-(9CI)(72693-02-8)

Safety Data

• Hazardous Substances Data: 72693-02-8(Hazardous Substances Data)

Upstream product

• 69971-38-6 Methyl-4,6-dimethyl-2-pyridincarboxylat 
• 108-47-4 2,4-lutidine 
• 77287-34-4 formamide 
• 18088-10-3 4,6-dimethylpyridine-2-carboxylic acid 
• 80206-42-4 4,6-dimethylpyridine-2-carboxylic acid ethyl ester 

Downstream Products

• 5407-87-4 2-Amino-4,6-dimethylpyridine 

Relevant articles and documents

Acid-Free Silver-Catalyzed Cross-Dehydrogenative Carbamoylation of Pyridines with Formamides

Primary pyridylcarboxamides are prevalent parent structures in bioactive molecules and have the apparent advantages over N-protected derivatives as synthetic building blocks. However, no practical methods have been developed for direct synthesis of this compound class from unfunctionalized pyridines. We herein present a general, safe, concise, acid-free, and highly selective method for the C2-carbamoylation of pyridines with unprotected formamide and N-methyl formamide through the cleavage of two C-H bonds.

Method for synthesizing pyridine primary amides by direct catalytic oxidation process

The invention discloses a method for synthesizing pyridine primary amides by a direct catalytic oxidation process. The method comprises the following steps: under the action of acid or alkali, adding an accelerator water and an oxidizer into formamide which is used as a carbonyl source and nitrogen source, and catalytically oxidizing double C-H bonds of pyridine or derivatives thereof under the action of a silver and/or iron catalyst to directly prepare the pyridine primary amides. By activating the double C-H bonds, the method disclosed by the invention has the advantages of ideal atomic economy, less generated waste, wide and stable substrate sources, and low price. Under the optimized reaction conditions, the separation yield of the target products is up to 98%.