727-18-4

Upstream product

• 762-04-9 Diethyl phosphonate 
• 4981-83-3 2-(Benzyloxy)ethyl p-toluenesulfonate 
• 1462-37-9 bromoethyl-2-benzyl ether 
• 122-52-1 triethyl phosphite 
• 622-08-2 2-Benzyloxyethanol 

Downstream Products

• 953-20-8 Ethyl-2-benzyloxyethylphosphonat 
• 622868-08-0 (2-Benzyloxy-ethyl)-phosphonic acid 
• 132155-68-1 [2-((R)-1-Phenyl-ethylcarbamoyloxy)-ethyl]-phosphonic acid diethyl ester 
• 132155-67-0 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-(diethoxy-phosphoryl)-ethyl ester 
• 22987-21-9 β-Hydroxyethanphosphonsaeure 

Relevant academic research and scientific papers

Compound, liquid crystal composition, liquid crystal display element, and liquid crystal display device

The present invention relates to a compound, a liquid crystal composition, a liquid crystal display element, and a liquid crystal display device, wherein the compound is represented by the following formula I, and the liquid crystal composition contains the compound represented by the formula I. According to the present invention, the compound represented by the formula I has advantages of good compatibility with other compounds and good ultraviolet resistance; and the compound as the reactive mesogen (RM) has advantages of good mutual solubility, high polymerization activity (less monomer residue), and strong binding ability, can be separately used as the self-aligning agent of a liquid crystal composition, can further be used as the self-aligning agent for the copolymerization of vertical alignment materials and other RM in PSA (polymer-supported alignment) and PS (polymer-stabilized) mode liquid crystal compositions, and can avoid PI process so as to simplify the process of liquid crystal display elements or liquid crystal displays and improve the production efficiency .

Enhanced Solubilization of Class B Radical S-Adenosylmethionine Methylases by Improved Cobalamin Uptake in Escherichia coli

The methylation of unactivated carbon and phosphorus centers is a burgeoning area of biological chemistry, especially given that such reactions constitute key steps in the biosynthesis of numerous enzyme cofactors, antibiotics, and other natural products of clinical value. These kinetically challenging reactions are catalyzed exclusively by enzymes in the radical S-adenosylmethionine (SAM) superfamily and have been grouped into four classes (A-D). Class B radical SAM (RS) methylases require a cobalamin cofactor in addition to the [4Fe-4S] cluster that is characteristic of RS enzymes. However, their poor solubility upon overexpression and their generally poor turnover has hampered detailed in vitro studies of these enzymes. It has been suggested that improper folding, possibly caused by insufficient cobalamin during their overproduction in Escherichia coli, leads to formation of inclusion bodies. Herein, we report our efforts to improve the overproduction of class B RS methylases in a soluble form by engineering a strain of E. coli to take in more cobalamin. We cloned five genes (btuC, btuE, btuD, btuF, and btuB) that encode proteins that are responsible for cobalamin uptake and transport in E. coli and co-expressed these genes with those that encode TsrM, Fom3, PhpK, and ThnK, four class B RS methylases that suffer from poor solubility during overproduction. This strategy markedly enhances the uptake of cobalamin into the cytoplasm and improves the solubility of the target enzymes significantly.

Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor β/δ agonists with neuroprotective activity

We report the pharmacophore of the peroxisome proliferator-activated receptor δ (PPARδ) agonist natural product phosphoiodyn A is the phosphonate core. Synthesis of simplified phosphonate esters 13 and 15 provide structurally novel, highly selective and potent PPARδ agonists (EC50 = 78 and 112 nM, respectively). Further, both compounds demonstrate significant neuroprotective activity in an in vitro cellular model indicating that phosphonates may be an effective novel scaffold for the design of therapeutics for the treatment of neurodegenerative disorders.

Synthesis of 3'-O-phosphonoethyl nucleosides with an adenine and a thymine base moiety

The synthesis and antiviral evaluation of new 3'-O-phosphonoethyl modified phosphonate nucleosides related to PMDTA and PMDTT is described. The reaction scheme starts from protected L-threose and the phosphonate group is introduced by the Arbuzov reaction. The 2'-OH as well as the 2'-deoxygenated nucleosides have been obtained. Unfortunately, none of these synthesized compounds shows activity against HIV and HCV.