727-81-1

Basic information

• Product Name: COENZYME Q1
• Synonyms: 2,3-DIMETHOXY-5-METHYL-6-(3-METHYL-2-BUTENYL)-1,4-BENZOQUINONE;COENZYME Q1;UBIQUINONE-5;2,3-dimethoxy-5-methyl-6-(3-methylbut-2-enyl)cyclohexa-2,5-diene-1,4-dione;Ubiquinone Q1;2,3-Dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone, Ubiquinone-1, Ubiquinone-5;2,3-Dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-2,5-cyclohexadiene-1,4-dione;2-Isopentenyl-5,6-dimethoxy-3-methyl-p-benzoquinone
• CAS NO: 727-81-1
• Molecular Formula: C₁₄H₁₈O₄
• Molecular Weight: 250.29
• Mol File: 727-81-1.mol

Chemical Properties

• Boiling Point: 389.1°C at 760 mmHg
• Flash Point: 172°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 2.92E-06mmHg at 25°C
• Refractive Index: 1.504
• Storage Temp.: −20°C
• CAS DataBase Reference: COENZYME Q1(CAS DataBase Reference)
• NIST Chemistry Reference: COENZYME Q1(727-81-1)
• EPA Substance Registry System: COENZYME Q1(727-81-1)

Safety Data

• Safety Statements: 23-24/25
• WGK Germany: 3
• Hazardous Substances Data: 727-81-1(Hazardous Substances Data)

Usage

Description

Cooenzyme Q10 (CoQ10) is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. CoQ1 is an amphipathic CoQ10 homolog that has a tail consisting of five isoprene units. It has been used as an electron acceptor to study a range of oxidoreductases as isolated enzymes, in subcellular fractions, in intact cells in culture, and in perfused organs. Ubiquinone analogs, including CoQ1, impact mitochondrial permeability transition pore (PTP) formation, as well as PTP-dependent cell death, in an analog- and cell-specific manner.

Uses

Different sources of media describe the Uses of 727-81-1 differently. You can refer to the following data:
1. Coenzyme Q1 has been used to measure the mitochondrial respiratory chain complex 1 activity.
2. Coenzyme Q1 is an electron acceptor and a component of the electron transport chain. It also play a role in the?mitochondrial permeability transition pore (PTP). Coenzyme Q1 is structurally similar to?coenzyme Q2 (C636450)?and?coenzyme Q10 (C636501).

General Description

Coenzyme Q (CoQ) is localized to the hydrophobic domain of the phospholipid bilayer of mitochondria, plasma lipoproteins, and other biological membranes. It is a ubiquinone homolog with a short isoprenoid side chain.

Biochem/physiol Actions

Coenzyme Q1 (CoQ1) is a 1 isoprenyl group (not naturally occurring) member of a family of ubiquinones that share a quinine chemical group but differ in the number of isoprenyl chemical subunits in their tail. The CoQ compounds are lipid soluble components of cell membranes where they perform multiple functions such as electron and proton transport. The most well studied CoQ compound is CoQ10. CoQ1 is frequently used in comparison studies on the effect of isoprenyl chain length on CoQ functions or distribution and to identify quinone reductases.

InChI:InChI=1/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3