727-94-6Relevant academic research and scientific papers
Synthesis of 3-acylindoles: via copper-mediated oxidative decarbethoxylation of ethyl arylacetates
Jaiswal, Anjali,Sharma, Anup Kumar,Singh, Krishna Nand
supporting information, p. 1623 - 1628 (2020/03/06)
An efficient regioselective C-3 acylation of free indoles (N-H) has been accomplished via oxidative decarbethoxylation of easily available ethyl arylacetates using Cu(OAc)2 and KOtBu in DMSO.
Decarboxylative acylation of: N -free indoles enabled by a catalytic amount of copper catalyst and liquid-assisted grinding
Yu, Jingbo,Zhang, Chao,Yang, Xinjie,Su, Weike
supporting information, p. 4446 - 4451 (2019/05/16)
A facile decarboxylative acylation of N-free indoles with α-ketonates via liquid-assisted grinding was reported. The reaction requires only a catalytic amount of Cu(OAc)2·H2O in combination with O2 as the terminal oxidant to give various 3-acylindoles with high efficiency. Additionally, this new methodology was applicable to a gram-scale synthesis.
Synthesis of 3-aroylindoles as intermediates of cannabimimetics and elucidation of their physicochemical properties
Araki, Koji,Makino, Kosho,Tabata, Hidetsugu,Nakayama, Hiroshi,Zaitsu, Kei,Oshitari, Tetsuta,Natsugari, Hideaki,Takahashi, Hideyo
, p. 910 - 920 (2018/06/07)
In order to synthesize the intermediates of cannabimimetics, the benzoylation of indoles with 2'/3'/4'-substituted benzoyl chloride in the presence of Et2AlCl was examined. Among the products, we found that the1H NMR spectra of 3-(2'-substitute
Synthesis of 3-acylindoles via decarboxylative cross-coupling reaction of free (NH) indoles with α-oxocarboxylic acids
Gu, Li-Jun,Liu, Ji-Yan,Zhang, Li-Zhu,Xiong, Yong,Wang, Rui
, p. 90 - 92 (2014/02/14)
A convenient and general method for acylation of free (NH) indoles via palladium-catalyzed decarboxylative cross-coupling reaction was developed. This process provided a useful method for the preparation of diverse 3-acylindoles in high yields utilizing a reaction with readily accessible reactants under mild conditions.
