72704-77-9Relevant academic research and scientific papers
One-pot green synthesis of 1,3,5-triarylpentane-1,5-dione and triarylmethane derivatives as a new class of tyrosinase inhibitors
Zheng, Zong-Ping,Zhang, Yi-Nan,Zhang, Shuang,Chen, Jie
, p. 795 - 798 (2016)
A new method was developed for one-pot green synthesis 1,3,5-triarylpentane-1,5-dione, triarylmethane, and flavonoid derivatives from the reaction between 2,4-dihydroxybenzaldehyde and hydroxyacetophenones via Aldol, Michael, and Friedel-Crafts additions
Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: A new target for a privileged structure
Balsera, Beatriz,Mulet, José,Fernández-Carvajal, Asia,Torre-Martínez, Roberto De La,Ferrer-Montiel, Antonio,Hernández-Jiménez, José G.,Estévez-Herrera, Judith,Borges, Ricardo,Freitas, Andiara E.,López, Manuela G.,García-López, M. Teresa,González-Mu?iz, Rosario,Pérez De Vega, María Jesús,Valor, Luis M.,Svobodová, Lucie,Sala, Salvador,Sala, Francisco,Criado, Manuel
, p. 724 - 739 (2015/02/19)
The α7 acetylcholine nicotine receptor is a ligand-gated ion channel that is involved in cognition disorders, schizophrenia, pain and inflammation among other diseases. Therefore, the development of new agents that target this receptor has great significance. Positive allosteric modulators might be advantageous, since they facilitate receptor responses without directly interacting with the agonist binding site. Here we report the search for and further design of new positive allosteric modulators having the relatively simple chalcone structure. From the natural product isoliquiritigenin as starting point, chalcones substituted with hydroxyl groups at defined locations were identified as optimal and specific promoters of α77 nicotinic function. The most potent compound (2,4,2-2,5-2-tetrahydroxychalcone, 111) was further characterized showing its potential as neuroprotective, analgesic and cognitive enhancer, opening the way for future developments around the chalcone structure.
Fluorinated 2′-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities
Padhye, Subhash,Ahmad, Aamir,Oswal, Nikhil,Dandawate, Prasad,Rub, Rukhsana A.,Deshpande, Jyoti,Swamy, K. Venkateswara,Sarkar, Fazlul H.
experimental part, p. 5818 - 5821 (2010/11/19)
Chalcones are involved in the synthesis of flavonoids and are themselves known to exhibit multiple pharmacological properties. However, compared to other structurally similar phytochemicals like garcinol and curcumin, the therapeutic use of chalcones is l
Anti-candida activity of synthetic hydroxychalcones
Tsuchiya,Sato,Akagiri,Takagi,Tanaka,Iinuma
, p. 756 - 758 (2007/10/02)
The antifungal activity of different synthetic hydroxychalcones was determined against Candida species. It was revealed that the presence of hydroxyl groups at C-2, C-4, and C-2' in chalcone was essential to inhibit Candida growth. Among the chalcone derivatives examined, 2,4,2'-trihydroxy-5'-methylchalcone showed the most intensive anti-Candida activity, suggesting that it could be a potential therapeutic agent for candidosis.
