72705-99-8Relevant academic research and scientific papers
On the thermal stability of [60]fullerene cycloadducts: Retro-cycloaddition reaction of 2-pyrazolino[4,5:1,2][60]fullerenes
Delgado, Juan Luis,Oswald, Frederic,Cardinali, Francois,Langa, Fernando,Martin, Nazario
, p. 3184 - 3188 (2008/09/19)
(Figure Presented) 2-Pyrazolino[4,5;1,2][60]fullerenes undergo a thermally induced retro-cycloaddition process whose efficiency is influenced by the nature of the C-substituent. C-Aryl-N-Aryl-2-pyrazolino[60]fullerenes (2a-d) poorly undergo a thermal retr
Aminyl and iminyl radicals from arylhydrazones in the photo-induced DNA cleavage
Hwu, Jih Ru,Lin, Chun Chieh,Chuang, Shih Hsien,King, Ke Yung,Su, Tzu-Rong,Tsay, Shwu-Chen
, p. 2509 - 2515 (2007/10/03)
Photolytic cleavage of the nitrogen-nitrogen single bond in benzaldehyde phenylhydrazones produced aminyl (R2N·) and iminyl (R2C=N·) radicals. This photochemical property was utilized in the development of hydrazones as photo-induced DNA-cleaving agents. Irradiation with 350nm UV light of arylhydrazones bearing substituents of various types in a phosphate buffer solution containing the supercoiled circular φX174 RFI DNA at pH6.0 resulted in single-strand cleavage of DNA. Attachment of the electron-donating OMe group to arylhydrazones increased their DNA-cleaving activity. Results from systematic studies indicate that both the aminyl and the iminyl radicals possessed DNA-cleaving ability.
