72708-57-7Relevant academic research and scientific papers
Arylation of lithium sulfinates with diaryliodonium salts: A direct and versatile access to arylsulfones
Umierski, Natalie,Manolikakes, Georg
, p. 4972 - 4975 (2013)
An efficient, transition-metal-free arylation of lithium sulfinates, which are readily accessible from reactions of organolithium reagents with sulfur dioxide, is described. Based on this method, a practical protocol for the direct transformation of (hetero)arenes and (hetero)aromatic halides into diarylsulfones was developed.
Efficient and Practical Synthesis of Sulfonamides Utilizing SO2 Gas Generated on Demand
Chung Leung, Gulice Yiu,Ramalingam, Balamurugan,Loh, Gabriel,Chen, Anqi
, p. 546 - 554 (2020/04/22)
A simple and practical protocol was developed for the synthesis of sulfonamides by reacting organometallic reagents with SO2 gas generated on demand. SO2 was generated from readily available reagents safely in a highly contained and controlled fashion. The protocol allows the synthesis of sulfonamides without using either atom-inefficient SO2 surrogates or a SO2 cylinder that requires stringent storage regulations in the laboratory. The protocol was successfully applied to the synthesis of sildenafil.
Copper-Catalyzed Remote para-C?H Functionalization of Anilines with Sodium and Lithium Sulfinates
Liang, Shuai,Bolte, Michael,Manolikakes, Georg
supporting information, p. 96 - 100 (2017/01/09)
A copper-catalyzed, cross-dehydrogenative coupling of anilines with sodium and lithium sulfinates was developed. By using a cooperative reaction system with Mn(OAc)3as stoichiometric co-oxidant a highly selective para-functionalization of anilines was accomplished. Various functional groups were tolerated and the desired products were obtained in high yields. This method not only provides a novel approach for the synthesis of arylsulfones but might also offer new opportunities for the development of copper-catalyzed para-selective C?H functionalizations.
Manganese(III) Acetate Mediated C–H Sulfonylation of 1,4-Dimethoxybenzenes with Sodium and Lithium Sulfinates
Liang, Shuai,Ren, Yueling,Manolikakes, Georg
supporting information, p. 4117 - 4120 (2017/08/07)
A simple and mild Mn(OAc)3-promoted oxidative coupling of 1,4-dimethoxybenzenes with sodium and lithium sulfinates was developed. The reaction proceeded readily at room temperature in air, and various sulfones were synthesized in moderate to high yields. In addition, a straightforward approach for the conversion of organolithium reagents and sulfur dioxide into sulfonylated 1,4-dimethoxybenzenes was explored.
Reductive Coupling of Aromatic Sulfinate Salts to Disulfides
Pinnick, Harold W.,Reynolds, Michael A.,McDonald, Robert T.,Brewster, Wanda D.
, p. 930 - 932 (2007/10/02)
A variety of aromatic sulfinate salts undergo reductive coupling to disulfides in the presence of ethyl hypophosphite.Support for the intermediacy of sulfoxy sulfones and thiosulfonates has been obtained.
