72717-05-6

Usage

General Description

The chemical 2-[[2-[(2-furylmethyl)thio]ethyl]amino]-5-[(6-methyl-3-pyridyl)methyl]-1H-pyrimidin-4-one is a compound with a molecular formula of C18H20N4OS. It is a derivative of pyrimidine and contains both a furan and a pyridine ring. 2-[[2-[(2-furylmethyl)thio]ethyl]amino]-5-[(6-methyl-3-pyridyl)methyl]-1H-pyrimidin-4-one has potential applications in pharmaceuticals and drug development, as it exhibits diverse biological activities and may have therapeutic properties. The specific functions and uses of this chemical, as well as any potential hazards or side effects, would require further study and research.

InChI:InChI=1/C18H20N4O2S/c1-13-4-5-14(10-20-13)9-15-11-21-18(22-17(15)23)19-6-8-25-12-16-3-2-7-24-16/h2-5,7,10-11H,6,8-9,12H2,1H3,(H2,19,21,22,23)

Upstream product

• 36415-21-1 2-[[[2-furanyl]methyl]thio]ethanamine 
• 72716-93-9 2-nitroamino-5-(6-methylpyrid-3-ylmethyl)-4(1H)-pyrimidone 
• 25902-86-7 2-methoxy-4(3H)-pyrimidinone 

Downstream Products

• 83903-06-4 Lupitidine 

Relevant academic research and scientific papers

Isocytosine H2-receptor histamine antagonists. III. The synthesis and biological activity of lupitidine (SK and F 93479) and related compounds

A series of 2-[2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino]-4-pyrimidones is described containing a variety of substituents in the 5-position of the pyrimidone (isocytosine) ring. Good H2-receptor histamine antagonist activity is retained over a range of basic and neutral, polar and non-polar substituents and the majority of compounds are selective for the H2-receptor. Modifications have also been made to the furan ring and N,N-dimethylaminomethyl substituent and structure-activity observations are discussed. Compound (16f) 2-[2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino]-5-(6-methyl-3- pyridylmethyl)-4-pyrimidone (SK and F 93479, lupitidine), a compound which shows an extended duration of anti-secretory activity in animal models, was selected for clinical investigation.

Chemical methods and intermediates for preparing substituted pyrimidinones

A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones. The new reactions and intermediates of this invention are particularly useful for preparing 2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidinone and its salts. This compound is a potent H2 -antagonist with a long duration of activity.