25902-86-7

Basic information

• Product Name: 4(1H)-Pyrimidinone, 2-methoxy- (9CI)
• Synonyms: 4(1H)-Pyrimidinone, 2-methoxy- (9CI);2-Methoxy-4(1H)-pyrimidinone;2-methoxypyrimidin-4-ol;4-Hydroxy-2-methoxypyrimidine;2-Methoxy-1,4-dihydropyriMidin-4-one;2-MethoxypyriMidin-4(1H)-one;2-Methoxypyrimidin-4-ol, 2-Methoxypyrimidin-4(3H)-one, 2-Methoxypyrimidin-4(1H)-one;4(1H)-Pyrimidinone, 2-methoxy-
• CAS NO: 25902-86-7
• Molecular Formula: C₅H₆N₂O₂
• Molecular Weight: 126.11334
• Product Categories: PYRIMIDINE
• Mol File: 25902-86-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 189.9°C at 760 mmHg
• Flash Point: 68.6°C
• Appearance: /
• Density: 1.306g/cm³
• Vapor Pressure: 0.556mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.23±0.40(Predicted)
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 2-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 2-methoxy- (9CI)(25902-86-7)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 2-methoxy- (9CI)(25902-86-7)

Safety Data

• Hazardous Substances Data: 25902-86-7(Hazardous Substances Data)

Usage

General Description

4(1H)-Pyrimidinone, 2-methoxy- (9CI) is a chemical compound with the molecular formula C5H6N2O2. It is a derivative of pyrimidinone and contains a methoxy group attached to the second position of the pyrimidinone ring. 4(1H)-Pyrimidinone, 2-methoxy- (9CI) can be used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is also known for its potential biological activities, making it an important molecule in medicinal chemistry research. Furthermore, it has various applications in industries such as agrochemicals, dyes, and polymers due to its versatile chemical structure. However, it is important to handle and use this chemical with care, as it may have potential hazards and should be used and stored according to proper safety protocols.

InChI:InChI=1/C5H6N2O2/c1-9-5-6-3-2-4(8)7-5/h2-3H,1H3,(H,6,7,8)

Upstream product

• 3289-47-2 4-amino-2-methoxypyrimidine 
• 63857-17-0 methyl 3-oxopropionate 
• 29427-58-5 O-methylisourea hemisulfate 
• 37117-02-5 1-(β-D-erythro-3-deoxy-pentofuranosyl)-4-methoxy-1H-pyrimidin-2-one 
• 931-63-5 2-methoxypyrimidine 

Downstream Products

• 717-00-0 1-benzyluracil 
• 61686-79-1 1-benzyl-3-methyl-2,4-pyrimidinedione 
• 253142-23-3 3-benzyl-2-methoxy-4-pyrimidinone 
• 72717-05-6 2-<2-(2-furanylmethylthio)ethylamino>-5-(6-methyl-3-pyridylmethyl)pyrimidin-4-one 

Relevant articles and documents

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Reactions of benzonitrile oxide with methoxypyrimidines and pyrimidones

Methoxypyrimidines preferentially add to benzonitrile oxide to give cycloadducts to their C=N double bonds. These, however, lose benzonitrile affording the corresponding pyrimidones. Cycloadditions to their C=C double bonds take place to a very low extent, and products generally undergo a ring opening process which affords the corresponding oximes. Pyrimidones preferentially give addition products to their nitrogen atoms, and only in the case of 4-pyrimidone, the cycloadduct to its C=C double bond was isolated.

A kinetic and nuclear magnetic resonance study of methylated pyrimidine nucleosides

Alkylated pyrimidine nucleosides are of interest from the viewpoint of mutagenesis and carcinogenesis. (1)H and (13)C nmr data are presented for a series of 2'-deoxynucleosides methylated at the O2-, O4-, and N3-positions of the base, and discussed in terms of their physical properties.The pH dependence of the stability of the O2- and O4-methylated 2'-deoxyribosides as well as the corresponding ribosides was examined by (1)H nmr and ultraviolet (uv) spectrophotometric methods.