72722-66-8Relevant academic research and scientific papers
Multidimensional de novo design reveals 5-HT2B receptor-selective ligands
Rodrigues, Tiago,Hauser, Nadine,Reker, Daniel,Reutlinger, Michael,Wunderlin, Tiffany,Hamon, Jacques,Koch, Guido,Schneider, Gisbert
supporting information, p. 1551 - 1555 (2015/01/30)
We report a multi-objective de novo design study driven by synthetic tractability and aimed at the prioritization of computer-generated 5-HT2B receptor ligands with accurately predicted target-binding affinities. Relying on quantitative bioactivity models we designed and synthesized structurally novel, selective, nanomolar, and ligand-efficient 5-HT2B modulators with sustained cell-based effects. Our results suggest that seamless amalgamation of computational activity prediction and molecular design with microfluidics-assisted synthesis enables the swift generation of small molecules with the desired polypharmacology.
Method for treating hypoxia
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, (2008/06/13)
A method for curing and/or improving hypoxia characterized by administering a compound represented by the general formula (1), STR1 said compounds have been known in prior art literatures, for example, as carbostyril derivatives in Japanese Patent Kokai N
Pharmaceutically useful carbostyril derivatives
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, (2008/06/13)
Carbostyril derivatives having antihistamic action and central nervous controlling action are useful as antihistamic agents or central nervous controlling agents. The derivatives are represented by the general formula, STR1 wherein R1 is a hydr
