72722-66-8

Basic information

• Product Name: 7-{3-[4-(3-chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril
• CAS NO: 72722-66-8
• Molecular Weight: 399.92
• Mol File: 72722-66-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 7-{3-[4-(3-chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril(CAS DataBase Reference)
• NIST Chemistry Reference: 7-{3-[4-(3-chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril(72722-66-8)
• EPA Substance Registry System: 7-{3-[4-(3-chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril(72722-66-8)

Safety Data

• Hazardous Substances Data: 72722-66-8(Hazardous Substances Data)

Upstream product

• 58022-96-1 7-(3-chloropropoxy)-3,4-dihydro-2(1H)-quinolinone 
• 6640-24-0 N-(m-chlorophenyl)piperazine 
• 22246-18-0 7-hydroxy-3,4-dihydro-2-(1H)-quinolinone 
• 52605-52-4 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride 

Relevant articles and documents

Multidimensional de novo design reveals 5-HT2B receptor-selective ligands

We report a multi-objective de novo design study driven by synthetic tractability and aimed at the prioritization of computer-generated 5-HT2B receptor ligands with accurately predicted target-binding affinities. Relying on quantitative bioactivity models we designed and synthesized structurally novel, selective, nanomolar, and ligand-efficient 5-HT2B modulators with sustained cell-based effects. Our results suggest that seamless amalgamation of computational activity prediction and molecular design with microfluidics-assisted synthesis enables the swift generation of small molecules with the desired polypharmacology.

Studies on 2(1H)-quinolinone derivatives as neuroleptic agents. I. Synthesis and biological activities of (4-phenyl-1-piperazinyl)-propoxy-2(1H)-quinolinone derivatives

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