72726-63-7 Usage
General Description
4-Hydroxymethyl-nicotinic acid, also known as 4-HMNA, is a chemical compound that is derived from nicotinic acid, also known as niacin or vitamin B3. It is an important intermediate in the biosynthesis of NAD+ (nicotinamide adenine dinucleotide), an essential coenzyme involved in cellular metabolism. 4-HMNA has been studied for its potential therapeutic properties, including its anti-inflammatory and antioxidant effects. It has also been investigated for its potential role in treating conditions such as diabetes, cardiovascular diseases, and neurodegenerative disorders. Overall, 4-Hydroxymethyl-nicotinic acid shows promise as a compound with medicinal properties and potential health benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 72726-63-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,7,2 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 72726-63:
(7*7)+(6*2)+(5*7)+(4*2)+(3*6)+(2*6)+(1*3)=137
137 % 10 = 7
So 72726-63-7 is a valid CAS Registry Number.
72726-63-7Relevant articles and documents
Comparison of Azabicyclic Esters and Oxadiazoles as Ligands for the Muscarinic Receptor
Orlek, Barry S.,Blaney, Frank E.,Brown, Frank,Clark, Michael S. G.,Hadley, Michael S.,et al.
, p. 2726 - 2735 (2007/10/02)
The link between the cognitive deficit associated with Alzheimer type dementia and the loss of cholinergic function in the disease provides a basis for examining muscarinic agonists as potential therapeutic agents.This paper describes the design and synthesis of novel azabicyclic methyl esters as ligands for the muscarinic receptor.Replacement of the methyl ester by a 3-methyl-1,2,4-oxadiazole ring produces potent metabolically more stable muscarinic agonists capable of penetrating the central nervous system.These compounds generally show improved affinity relativeto the corresponding methyl esters. 3-Methyl-1,2,4-oxadiazole 7b has an affinity 4 times that of acetylcholine.Receptor affinity is discussed in relation to the size and geometry of the azabicyclic ring and the electronic properties of the heteroaromatic ring.
