130513-77-8

Basic information

• Product Name: 1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, exo- (9CI)
• Synonyms: 1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, exo- (9CI)
• CAS NO: 130513-77-8
• Molecular Formula: C₇H₁₀ClNO
• Molecular Weight: 159.6134
• Product Categories: ACIDHALIDE
• Mol File: 130513-77-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, exo- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, exo- (9CI)(130513-77-8)
• EPA Substance Registry System: 1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, exo- (9CI)(130513-77-8)

Safety Data

• Hazardous Substances Data: 130513-77-8(Hazardous Substances Data)

Upstream product

• 3393-45-1 5,6-dihydro-pyran-2-one 
• 114704-10-8 endo-ethyl 1-azabicyclo[2.2.1]heptane-3-carboxylate 
• 133366-42-4 cis-2-benzylhexahydropyrano<3,4-c>pyrrol-4(3aH)-one 
• 115595-00-1 (1R,3S,4R)-1-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid 
• 118796-92-2 Hexahydro-furo[3,4-c]pyridin-3-one 
• 72726-63-7 4-(Hydroxymethyl)nicotinic acid 
• 133745-58-1 (1R,3S,4S)-1-Benzyl-3-ethoxycarbonyl-1-azonia-bicyclo[2.2.1]heptane; bromide 
• 114704-10-8 (1R,3R,4R)-1-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid ethyl ester 
• 133745-56-9 (3S,4S)-1-Benzyl-4-bromomethyl-piperidine-3-carboxylic acid ethyl ester 
• 133745-54-7 cis-5-benzyl-3a,4,5,6,7,7a-hexahydrofuro<3,4-c>pyridin-3(1H)-one 
• 4664-08-8 cinchomeronic anhydride 
• 5657-52-3 1,3-dihydrofuro<3,4-c>pyridin-3-one 
• 115595-00-1 (1S,3S,4S)-1-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid 

Downstream Products

• 121564-89-4 exo-3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo<2.2.1>heptane 
• 123916-90-5 endo-3-acetyl-1-azabicyclo<2.2.1>heptane 

Relevant articles and documents

Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands

The effect of variation of the 1-azabicyclic substituent on the novel 1,2,3-triazol-4-yl-, 1,2,4-triazol-1-yl-, tetrazol-5-yl-, and tetrazol-2-yl- based muscarinic receptor ligands has been studied, and the exo- azabicyclic[2.2.1]hept-3-yl substituent was found to give the most potent and efficacious compounds. In addition, variation of the second substituent on 1,2,4-triazol-1-yl- and tetrazol-2-yl-based muscarinic receptor ligands has yielded a series of novel compounds with high potencies and efficacies, ranging from full agonists to antagonists. Small lipophilic electron withdrawing substituents give potent but low efficacy compounds, while small polar electron donating substituents give potent and efficacious compounds. The activity of these compounds is described in terms of a model of the receptor involving lipophilic and hydrogen bonding interactions. These compounds provide muscarinic ligands with high potency and a range of efficacies suitable for testing as candidate drugs in the treatment of Alzheimer's disease.