72732-15-1Relevant articles and documents
Hf(OTf)4-Catalyzed regioselective N -aminomethylation of indoles and related NH-containing heterocycles
Sakai, Norio,Shimamura, Kazuyori,Ikeda, Reiko,Konakahara, Takeo
supporting information; experimental part, p. 3923 - 3926 (2010/07/05)
Figure presented Under Lewis acidic conditions using Hf(OTf)4, the aminomethylation of an indole derivative with a typical N,O-acetal preferentially produced kinetically favored N-aminomethylated indole derivatives instead of thermodynamically favored 3-aminomethylated indoles.
Synthesis, pharmacological screening, quantum chemical and in vitro permeability studies of N-Mannich bases of benzimidazoles through bovine cornea
Jesudason, E. Philip,Sridhar,Malar, E.J. Padma,Shanmugapandiyan,Inayathullah, Mohammed,Arul,Selvaraj,Jayakumar
experimental part, p. 2307 - 2312 (2009/09/30)
A novel series of N-Mannich bases of benzimidazole derivatives were synthesized and characterized by 1H NMR, IR spectral studies and elemental analysis. The compounds were screened for analgesic and anti-inflammatory activity. 1-((Diethylamino)-methyl)-2-styryl benzimidazole 4 at 40 mg/kg was found to be equipotent to paracetamol. 1-((Piperidin-1-yl) methyl)-2-styryl-benzimidazole 6 at 40 mg/kg was found to be more potent than Diclofenac. Corneal permeability and quantum chemical calculations were performed to correlate the hydrogen bonding ability with permeability and activity. The energies of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) were correlated with pharmacological activity. The semi-empirical PM3 calculations (quantum chemical calculations) revealed that ELUMO and energy gap ΔE were capable of accounting for the high in vitro bovine corneal permeability and activity of the compounds.
