727374-91-6

Upstream product

• 400-31-7 1,1,1-trifluoro-4-methyl-pent-3-en-2-one 
• 188132-02-7 (5-fluoro-2-methoxyphenyl)magnesium bromide 
• 609806-82-8 1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-one 
• 271587-47-4 2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane 
• 611-36-9 quinolin-4-ol 

Downstream Products

• 727375-45-3 1-[4-(5-fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one 
• 1025921-27-0 1-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]-1,2,3,4-tetrahydroquinolin-4-ol 

Relevant academic research and scientific papers

Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists

We report on the nuclear receptor binding affinities, cellular activities of transrepression and transactivation, and anti-inflammatory properties of a quinol-4-one and other A-ring mimetic containing nonsteroidal class of glucocorticoid agonists.

1-PROPANOL AND 1-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS

Compounds of Formula (I) wherein R1, R2 R3, R4, R5, R6, and X are as defiend herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocoricoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.