727665-66-9Relevant academic research and scientific papers
Novel titanocene anti-cancer drugs derived from fulvenes and titanium dichloride
Tacke, Matthias,Allen, Lorcan T.,Cuffe, Laurence,Gallagher, William M.,Lou, Ying,Mendoza, Oscar,Müller-Bunz, Helge,Rehmann, Franz-Josef K.,Sweeney, Nigel
, p. 2242 - 2249 (2007/10/03)
Starting from 6-(p-N,N-dimethylanilinyl)fulvene (1a) or 6-(pentamethylphenyl)fulvene (1b) [1,2-di(cyclopentadienyl)-1,2-di (p-N,N-dimethylaminophenyl)ethanediyl] titanium dichloride (2a) and [1,2-di(cyclopentadienyl)-1,2-bis(pentamethylphenyl)ethanediyl] titanium dichloride (2b) and their corresponding dithiocyanato complexes (3a, 3b) were synthesized. Titanocene 2b did not show a cytotoxic effect, but when 2a was tested against pig kidney carcinoma cells (LLC-PK) or human ovarian carcinoma cells (A2780/cp70) inhibitory concentrations (IC50) of 2.7 × 10-4 and 1.9 × 10-4 M, respectively, were observed.
