727675-17-4Relevant academic research and scientific papers
Gold(I)-Catalyzed 1,3-O-Transposition Reactions: Ynesulfonamides to Ynamides
Li, De-Yao,Wei, Yin,Shi, Min
, p. 4108 - 4113 (2015)
The gold-catalyzed 1,3-O-transposition reaction of ynesulfonamides provides a practical synthetic protocol for the synthesis of ynamides under mild conditions. This is the first 1,3-O-transposition example of ynesulfonamides in which a heteroatom is attached to the alkynyl terminal. A plausible mechanism is been proposed on the basis of 18O-labeling and control experiments as well as DFT calculation. By simple treatment, the obtained ynamides can easily be transformed into useful products. The gold-catalyzed 1,3-O-transposition reaction of ynesulfonamides provides a practical synthetic protocol for the synthesis of ynamides under mild conditions. This is the first 1,3-O-transposition example of ynesulfonamides in which a heteroatom is attached to the alkynyl terminal.
Co(II)/Ag(I) Synergistically Catalyzed Monoinsertion Reaction of Isocyanide to Terminal Alkynes with H2O: Synthesis of Alkynamide Derivatives
Zhang, Rong,Gu, Zheng-Yang,Wang, Shun-Yi,Ji, Shun-Jun
supporting information, p. 5510 - 5514 (2018/09/13)
A Co(II)/Ag(I) synergistically catalyzed three-component reaction of isocyanide with terminal alkyne and water to afford alkynamide derivatives is reported. The insertion of monoisocyanide into the C-H bond of terminal alkynes is an efficient, straightforward, atom-economical route to alkynamides, which are useful synthons in organic synthesis. This synergistic process achieves the cleavage of a C-H bond and the construction of new C-C and Ca?O bonds under mild conditions through the reaction of Co(II)-activated isocyanides and a Ag(I)-complex-activated terminal alkyne. This reaction has broad substrate versatility and functional group tolerance.
