72769-03-0Relevant articles and documents
Pyridine?BrF3, the missing link for clean fluorinations of aromatic derivatives
Hagooly, Youlia,Rozen, Shlomo
supporting information; experimental part, p. 1114 - 1117 (2012/04/10)
This work demonstrates the unique features of the never used before Py?BrF3 complex in the field of aromatic organic fluorinations. The main disadvantage of the noncomplexed BrF3 is the fact that usually, in addition to the desired fluorination, a parallel electrophilic aromatic bromination takes place as well. Use of the Py?BrF3 complex reduces this electrophilic bromination, which is observed with most reagents based on fluorine and bromine [BrF].
A homologous series of O- and N-functionalized 2,2-difluoro-1,3-benzodioxoles: An exercise in organometallic methodology
Schlosser, Manfred,Gorecka, Joanna,Castagnetti, Eva
, p. 452 - 462 (2007/10/03)
The conversion of 2,2-difluoro-1,3-benzodioxole, an exceptionally acidic arene, via a 4-lithiated intermediate into more than three dozen new derivatives was conceived as a case study. The lithiated species was trapped by C0-electrophiles (4-toluenesulfonyl azide, fluorodimethoxyborane, iodine), C1-electrophiles (carbon dioxide, N,N-dimethylformamide, formaldehyde, dimethyl sulfate), C2-electrophiles (oxalic acid diesters, oxirane), C3-electrophiles (oxetane), and higher alkyl iodides. The resulting carboxylic acid 1a may be treated with organolithium compounds to afford ketones (e.g. 10) and the aldehyde 9 can be condensed with nitromethane or acetic anhydride under basic conditions. If not oxidized with chromium trioxide to the corresponding carboxylic acids, the alcohols 2b, 2c, and 2d can be transformed into the corresponding bromides (12) or sulfonates (13). Their condensation with nitrogen-containing C0-nucleophiles (hydroxylamine, sodium azide, potassium phthalimide), C1-nucleophiles (potassium cyanide), and C2-nucleophiles (aceto-nitrile) opens a convenient access to the amines 3. Other reactions gave, despite a proven track record in other areas, only moderate yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
Circulation-active dioxyalkylenearyl-dihydropyridines
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, (2008/06/13)
Circulation-active dihydropyridines of the formula STR1 in which R1 is H, CN, NO2 or --COOR7, R7 is H, alkyl or various other radicals, R2 and R4 each independently is alkyl or other radicals, R3 is H or optionally substituted alkyl, and R5 completes a keto or ester group, and physiologically acceptable salts thereof. Also the aldehyde intermediate therefor of the formula STR2
Circulation-active dioxyalkylenearyl-dihydropyridines
-
, (2008/06/13)
Circulation-active dihydropyridines of the formula STR1 in which R1 is H, CN, NO2 or --COOR7, R7 is H, alkyl or various other radicals, R2 and R4 each independently is alkyl or other radicals, R3 is H or optionally substituted alkyl, R5 completes a keto or ester group, and R6 is a direct bond or --CF2 -- or --CHF--, and physiologically acceptable salts thereof.
