727723-14-0Relevant articles and documents
Novel routes for the generation of structurally diverse labdane diterpenes from andrographolide
Nanduri, Srinivas,Nyavanandi, Vijay Kumar,Thunuguntla, Siva Sanjeeva Rao,Velisoju, Mahendar,Kasu, Sridevi,Rajagopal, Sriram,Kumar, R. Ajaya,Rajagopalan,Iqbal, Javed
, p. 4883 - 4886 (2004)
Andrographolide 1, the major constituent of the Indian medicinal plant Andrographis paniculata (Acanthaceae) was converted into the key intermediate 4 by selective oxidative degradation of the C-12,13 olefin bond. The aldehyde functional group present in 4 has been utilized for synthesizing a number of structurally diverse labdane diterpenes. Synthesis and in vitro cytotoxic activity results of the compounds prepared are discussed.