7278-51-5

Basic information

• Product Name: 1,3-DIMETHYL-6-PHENYLAMINO-URACIL
• Synonyms: AURORA KA-4952;1,3-DIMETHYL-6-PHENYLAMINO-URACIL;6-Anilino-1,3-dimethyluracil
• CAS NO: 7278-51-5
• Molecular Formula: C₁₂H₁₃N₃O₂
• Molecular Weight: 231.25
• Mol File: 7278-51-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 186-188℃
• Boiling Point: 353.1°Cat760mmHg
• Flash Point: 167.4°C
• Appearance: /
• Density: 1.300
• Vapor Pressure: 3.66E-05mmHg at 25°C
• Refractive Index: 1.64
• CAS DataBase Reference: 1,3-DIMETHYL-6-PHENYLAMINO-URACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIMETHYL-6-PHENYLAMINO-URACIL(7278-51-5)
• EPA Substance Registry System: 1,3-DIMETHYL-6-PHENYLAMINO-URACIL(7278-51-5)

Safety Data

• Hazardous Substances Data: 7278-51-5(Hazardous Substances Data)

Usage

Synonyms

DPHMU

Chemical class

Uracil derivatives

Physical state

White crystalline solid

Molecular weight

228.24 g/mol

Uses

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Potential applications

Antitumor and antiviral activities

Chemical structure

Uracil ring with a dimethyl group at the 1 and 3 positions, and a phenylamino group at the 6 position

Pharmacological activities

Unique properties and potential applications in medicinal chemistry

InChI:InChI=1/C12H13N3O2/c1-14-10(8-11(16)15(2)12(14)17)13-9-6-4-3-5-7-9/h3-8,13H,1-2H3

Upstream product

• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 62-53-3 aniline 

Downstream Products

• 74698-07-0 5-(4-Bromo-phenyl)-1,3-dimethyl-5,10-dihydro-1H-pyrimido[4,5-b]quinoline-2,4-dione 
• 105159-32-8 4-methyl-N-(2-phenyl-2-(phenylamino)ethyl)benzenesulfonamide 
• 105167-93-9 C₂₅H₂₆N₆O₄ 
• 105159-28-2 N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide 
• 105159-20-4 C₄₃H₄₄N₄O₄S₂ 
• 39260-04-3 1,3-dimethylpyrimido<4,5-b>quinoline-2,4(1H,3H)-dione 
• 77603-14-6 methyl 4-anilino-1,3-dimethyluracil-5-dithiocarboxylate 
• 137557-00-7 methyl N-phenyl-N-(1,3-dimethyluracil-4-yl)dithiocarbamate 
• 137278-09-2 1,3-dimethyl-5-hydroxy-8-phenyl-1,2,3,4,7,8-hexahydropyrido<2,3-d>pyrimidine-2,4,7-trione 
• 1448799-83-4 6-anilino-5-(2,2,3,3,4,4,4-heptafluorobutanoyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 1448799-82-3 6-anilino-1,3-dimethyl-5-(trifluoroacetyl)pyrimidine-2,4(1H,3H)-dione 
• 137557-05-2 ethyl α-benzoyl-1,3-dimethyl-2,4-dioxo-2H,4H-pyrimido<4,5-b>quinoline-5-acetate 
• 137557-07-4 α-benzoyl-α-(1,3-dimethyl-2,4-dioxo-2H,4H-pyrimido<4,5-b>quinolin-5-yl)acetone 
• 137557-02-9 5-benzylamino-1,3-dimethylpyrimido<4,5-b>quinoline-2,4(1H,3H)dione 

Relevant articles and documents

Synthesis and reactivity of 5-polyfluoroalkyl-5-deazaalloxazines

Reaction of 6-arylamino-1,3-dialkyluracils with anhydrides of polyfluorocarboxylic acids in the presence of pyridine and subsequent cyclization with concentrated H2SO4 gave the corresponding 1,3-dialkyl-5-(polyfluoroalkyl)pyrimido[4,

Synthesis of substituted uracils by the reactions of halouracils with selenium, sulfur, oxygen and nitrogen nucleophiles under focused microwave irradiation

Under microwave irradiation, the nucleophilic substitution reactions of halouracils with selenium, sulfur, oxygen and nitrogen nucleophiles was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to th

Ring closure reactions of cyclic 2-arylaminomethylene-1,3-diones

5-Arylaminomethylene compounds such as 5-arylaminomethylenepyrimidine-2,4,6-triones 2 or 2-phenylaminomethylenephenalene-1,3-dione 13 cyclize by thermolysis via migration of the arylamino group to pyrimido[4,5-b]quinoline-2,4-diones 6 or 7-oxo-7H-naphtho[