72795-01-8 Usage
Description
ICI 118551 is a potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively). It is active in vivo and is often used to evaluate the actions of adrenergic receptor agonists.
Uses
Different sources of media describe the Uses of 72795-01-8 differently. You can refer to the following data:
1. ICI 118,551 hydrochloride has been used:to block β-adrenergic signaling in various experimentsto counteract degradation by endogenous T-lymphocyte monoamine oxidasesto determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts
2. The (R,R)-enantiomer
3. The (R,R)-enantiomer of ICI 118551 as highly selective β2-adrenoceptor antagonist. The S,S-enantiomer is the most potent.
Biochem/physiol Actions
ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.
Check Digit Verification of cas no
The CAS Registry Mumber 72795-01-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,7,9 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 72795-01:
(7*7)+(6*2)+(5*7)+(4*9)+(3*5)+(2*0)+(1*1)=148
148 % 10 = 8
So 72795-01-8 is a valid CAS Registry Number.
