727974-65-4

Basic information

• Product Name: N,N-dimethyl-N-[2-(3-{[2-(trifluoromethoxy)phenyl]sulfonyl}-1H-indol-1-yl)ethyl]amine
• Synonyms: N,N-dimethyl-N-[2-(3-{[2-(trifluoromethoxy)phenyl]sulfonyl}-1H-indol-1-yl)ethyl]amine
• CAS NO: 727974-65-4
• Molecular Weight: 412.433
• Mol File: 727974-65-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-N-[2-(3-{[2-(trifluoromethoxy)phenyl]sulfonyl}-1H-indol-1-yl)ethyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-N-[2-(3-{[2-(trifluoromethoxy)phenyl]sulfonyl}-1H-indol-1-yl)ethyl]amine(727974-65-4)
• EPA Substance Registry System: N,N-dimethyl-N-[2-(3-{[2-(trifluoromethoxy)phenyl]sulfonyl}-1H-indol-1-yl)ethyl]amine(727974-65-4)

Safety Data

• Hazardous Substances Data: 727974-65-4(Hazardous Substances Data)

Upstream product

• 87482-09-5 2-(1H-indol-1-yl)-N,N-dimethylethan-1-amine 
• 103008-51-1 2-(trifluoromethoxy)benzenesulfonyl chloride 
• 175278-01-0 2-(trifluoromethoxy)thiophenol 
• 98-95-3 nitrobenzene 
• 120-72-9 indole 
• 124-40-3 dimethyl amine 

Relevant articles and documents

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands

Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively. Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively.