727992-64-5Relevant academic research and scientific papers
AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS
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Page/Page column 27, (2009/02/11)
The present invention provides a compound of formula I: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
Synthesis of benzimidazoles from 1,1-dibromoethenes
Shen, Wang,Kohn, Todd,Fu, Zice,Jiao, XianYun,Lai, Sujen,Schmitt, Michael
scheme or table, p. 7284 - 7286 (2009/04/11)
A mild and efficient method for the preparation of substituted benzimidazoles from 1,1-dibromoethenes and o-diaminobenzenes is described. The reaction employs DABCO as the base and NMP as the solvent. A variety of substitutions on both 2-aryl-1,1-dibromoethenes and o-diaminobenzenes are tolerated. This new procedure is carried out under mildly basic conditions, which may provide a complementary route to the existing preparations of benzimidazoles.
N-substituted-azacyclylamines as histamine-3 antagonists
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Page/Page column 31, (2010/11/28)
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis
Beaulieu, Christian,Wang, Zhaoyin,Denis, Danielle,Greig, Gillian,Lamontagne, Sonia,O'Neill, Gary,Slipetz, Deborah,Wang, Jennifer
, p. 3195 - 3199 (2007/10/03)
A series of 2-substituted N-benzyl benzimidazole containing molecules has been synthesized and its structure-activity relationship for the human DP receptor has been evaluated. Selective DP antagonists with nanomolar potency for the DP receptor were identified in this novel series of benzimidazoles.
