727993-34-2

Usage

Uses

Used in Organic Synthesis:
6-methoxy-2-(trifluoromethyl)pyridin-3-amine is utilized as a key intermediate in organic synthesis for the creation of complex organic molecules. Its presence of both electron-donating and electron-withdrawing groups allows for versatile reactivity and the formation of a wide range of compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 6-methoxy-2-(trifluoromethyl)pyridin-3-amine is employed as a building block for the synthesis of biologically active molecules. Its unique structure contributes to the development of new pharmaceutical agents with potential therapeutic benefits.
Used in Drug Development:
6-methoxy-2-(trifluoromethyl)pyridin-3-amine is used as a valuable tool in drug development. Researchers leverage its chemical properties to design and synthesize new drugs and therapeutic agents, aiming to address various medical conditions and improve patient outcomes.

Upstream product

• 727993-33-1 6-methoxy-3-nitro-2-(trifluoromethyl)pyridine 
• 38533-61-8 2-chloro-6-methoxy-3-nitropyridine 

Downstream Products

• 503184-34-7 3-iodo-6-methoxy-2-(trifluoromethyl)pyridine 
• 503184-37-0 2'-benzyloxy-6-methoxy-3'-nitro-2-trifluoromethyl-[3,4']bipyridinyl 

Relevant academic research and scientific papers

Therapeutically Active Thiazolo-Pyrimidine Derivatives

A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

THERAPEUTICALLY ACTIVE THIAZOLO-PYRIMIDINE DERIVATIVES

A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

COMPOUNDS AS CRF1 RECEPTOR ANTAGONISTS

The present invention relates to compounds of Formula I,or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The compounds of the inventions are CRF, receptor antagonists. Compounds of the invention are useful for t

HETEROARYL- SUBSTITUTED PYRROLO` 2, 3- B! PYRIDINE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS

The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof, to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF).

CRF ligands via Suzuki and Negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine.

A series of imidazo[4,5-b]pyridines with a 7-(3-pyridyl) substituent is described as high affinity CRF receptor ligands. Individual analogues were synthesized from key intermediates obtained via palladium-catalyzed coupling of 3-pyridyl zinc or boronic acid organometallic intermediates with 2-benzyloxy-4-chloro-3-nitropyridine 12.