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Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 371-42-6 4-Fluorothiophenol 
• 124644-96-8 ethyl 2-(4-fluorophenylthiomethyl)benzoate 
• 7115-91-5 2-ethoxycarbonylbenzyl bromide 
• 87-24-1 ethyl 2-methylbenzoate 
• 118-90-1 ortho-methylbenzoic acid 

Downstream Products

• 124644-96-8 ethyl 2-(4-fluorophenylthiomethyl)benzoate 
• 139305-28-5 (E)-1-(2-Fluoro-6,11-dihydrodibenzothiepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine oxalate 

Relevant academic research and scientific papers

Pyridazone derivative and its uses

The present invention belongs to the pharmaceutical field, specifically relates to a pyridazone derivative and its uses, compounds thereof and pharmaceutically acceptable salts, solvates including hydrates, polycrystallines, prodrugs, co-crystallines, tau

Synthesis and biological activity of 11-[4-(cinnamyl)-1-piperazinyl]-6,11-dihydrodibenz[b,e]oxepin derivatives, potential agents for the treatment of cerebrovascular disorders

A series of 11-[4-(cinnamyl)-1-piperazinyl]-6,11-dihydrodibenz[b,e]oxepins and related compounds were synthesized and evaluated for their protective activities against complete ischemia, normobaric hypoxia, lipidperoxidation and convulsion. Structure-activity relationship studies of this series led to the finding of (E)-1-(3-fluoro-6,11-dihydrodibenz[b,e]oxepin-11-yl)-4-(3-phenyl-2-prop enyl)piperazine dimaleate (50), AJ-3941 with the most appropriate property for combined pharmacological activities. Compound 50 also shows an inhibitory effect against cerebral edema as well when orally given to rats.