728024-41-7

Usage

Appearance

Fluorescent yellow solid A visually noticeable, bright yellow-colored solid with fluorescent properties.

Molecular weight

247.28 g/mol The mass of one mole of 1-benzyl-5-fluoro-1H-indole-3-carbaldehyde, measured in grams per mole.

Benzyl group

A phenyl ring attached to a methyl group A functional group consisting of a benzene ring (a six-carbon ring with alternating single and double bonds) connected to a single carbon atom (methyl group).

Fluorine atom

A halogen element attached to the 1H-indole ring A highly electronegative element from the halogen group, present in the compound at the 5-position of the 1H-indole ring.

1H-indole ring

A five-membered aromatic ring with a nitrogen atom A heterocyclic aromatic ring system consisting of five atoms, including one nitrogen atom, and having delocalized electrons across the ring.

Aldehyde functional group

An oxygen atom double-bonded to a carbon atom at the 3-carbon position A carbonyl group (C=O) with only one hydrogen atom attached to the carbonyl carbon, indicating the presence of an aldehyde.

Upstream product

• 2338-71-8 5-fluoro-1H-indole-3-carbaldehyde 
• 399-52-0 5-fluoro-1H-indole 
• 100-39-0 benzyl bromide 

Downstream Products

• 1360583-81-8 dimethyl 2-(1-benzyl-5-fluoro-1H-indol-3-yl)cyclopropane-1,1-dicarboxylate 
• 1360583-75-0 dimethyl 2-[(1-benzyl-5-fluoro-1H-indol-3-yl)methylene]malonate 

Relevant academic research and scientific papers

Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5-HT1AR/SERT

A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the highest affinities at the 5-HT1AR (Ki = 43 and 56 nM), whereas compounds 11c and 14a were the most potent analogs at the SERT (Ki = 34 and 17 nM). On the other hand, compounds 14b and 11d showed potent activity at both targets, displaying a profile that makes them promising leads for the search for novel potent ligands with a dual mechanism of action. Molecular docking studies in all the compounds unveiled relevant drug–target interactions, which allowed rationalizing the observed affinities.

Domino cyclodimerization of indole-derived donor-acceptor cyclopropanes: One-step construction of the pentaleno[1,6-a,b]indole skeleton

The fellowship of the rings: The previously undiscovered ability of indole-derived donor-acceptor cyclopropanes to involve four reaction centers simultaneously was revealed by their domino cyclodimerization (see scheme). This SnCl4-induced reac