72803-02-2Relevant articles and documents
A preparation containing [...] method for synthesizing of antihypertensive medicines we surround class
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, (2017/01/17)
The invention relates to a synthesis method for preparing an antihypertensive medicine having a benzofuroxan ring. In the method, 4-methylbenzofuroxan is used as a raw material, the 2,1,3-benzoxadiazole-4-aldehyde serving as an important intermediate is prepared by bromination and oxidation reactions, and the 2,1,3-benzoxadiazole-4-aldehyde and acetoacetic ester undergo a Hantzsch reaction to form the target compound. Compared with other processes, the method has the characteristics of mild reaction conditions, simple and efficient operation, high yield and the like and has a certain industrial production prospect.
Synthesis of asymmetric 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates with vasodilating and antihypertensive activities
Ohno,Komatsu,Mizukoshi,Ichihara,Nakamura,Morishima,Sumita
, p. 1589 - 1606 (2007/10/02)
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