728044-69-7Relevant academic research and scientific papers
CATALYTIC CANNABINOID PROCESSES AND PRECURSORS
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, (2020/12/07)
The present disclosure relates to new cannabinoid sulfonate esters and processes for their use to prepare cannabinoids. The disclosure also relates to the use of catalysts and catalytic processes for the preparation of cannabinoids from the cannabinoid sulfonate esters.
Biomimetic Cannabinoid Synthesis Revisited: Batch and Flow All-Catalytic Synthesis of (±)-ortho-Tetrahydrocannabinols and Analogues from Natural Feedstocks
Giorgi, Pascal D.,Liautard, Virginie,Pucheault, Mathieu,Antoniotti, Sylvain
, p. 1307 - 1311 (2018/04/02)
Using a combination of Au nanoparticle-catalyzed oxidation under an O2 atmosphere and a Ti-doped montmorillonite (Ti-MMT)-catalyzed tandem arylation/double cyclization, we developed an original and highly selective method for the synthesis of ortho-tetrahydrocannabinol derivatives from simple substrates. The reaction sequence could be performed in two steps in batch mode or in a single operation in continuous-flow reactors. The abnormal regioselectivity was proposed to be the result of the non-innocent role of the MMT support, TiIV cation coordination, and a Lewis acid-assisted Br?nsted acid (LBA) mechanism.
Synthesis of the alkenyl-substituted tetracyclic core of the bisabosquals
Zhou, Jingye,Lobera, Mercedes,Neubert-Langille, Bobbianna J.,Snider, Barry B.
, p. 10018 - 10024 (2008/02/13)
HCl-catalyzed deprotection and cyclization of benzylic alcohol 15 cleanly provided tricycle 16 by a cis-selective intramolecular Diels-Alder reaction. Acetylation of the phenol, bis epoxidation, and base-catalyzed hydrolysis and cyclization afforded tetra
