72807-56-8

Basic information

• Product Name: 3,3-dimethyl-N-phenylbutanamide
• Synonyms: Acetanilide, 2-tert-butyl-
• CAS NO: 72807-56-8
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.2695
• Mol File: 72807-56-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 337.4°C at 760 mmHg
• Flash Point: 201.1°C
• Density: 1.014g/cm³
• Vapor Pressure: 0.000105mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 3,3-dimethyl-N-phenylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-dimethyl-N-phenylbutanamide(72807-56-8)
• EPA Substance Registry System: 3,3-dimethyl-N-phenylbutanamide(72807-56-8)

Safety Data

• Hazardous Substances Data: 72807-56-8(Hazardous Substances Data)

Upstream product

• 26153-90-2 N,N-dimethyl-tert-butylacetamide 
• 142-04-1 aniline hydrochloride 
• 144691-18-9 N-methyl-N-phenyl-3,3-dimethylbutanamide 
• 7065-46-5 3,3-dimethylbutanoic acid chloride 
• 100-61-8 N-methylaniline 
• 201230-82-2 carbon monoxide 
• 5362-74-3 pivalaldehyde N-tosylhydrazone 
• 62-53-3 aniline 
• 4379-33-3 2-(tert-butyl)malonic acid 
• 1070-83-3 tert-Butylacetic acid 
• 103-71-9 phenyl isocyanate 
• 72807-52-4 1-(3,3-dimethyl-but-1-ynylsulfanyl)-3-methyl-but-2-ene 

Downstream Products

• 107574-59-4 5-(2,2-Dimethylpropyl)-1-phenyl-1H-tetrazol 

Relevant articles and documents

An Environmentally Benign, Catalyst-Free N?C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides

Herein, we report an operationally simple, cheap, and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol is environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy has been implied in the chemoselective synthesis of a pharmaceutical molecule, paracetamol, on a gram-scale with excellent yield. We anticipate that this universally applicable strategy will be of great interest in drug discovery, biochemistry, and organic synthesis.

N-demethylation method for amide and application thereof

The invention discloses an N-demethylation method for amide and application thereof. The method comprises the following steps: heating raw amide to 40-120 DEG C under the action of N-fluorodibenzenesulfonamide and a bivalent copper salt, and carrying out a reaction to obtain demethylated amide. The chemical structural formula of the raw amide is described in the specification; the chemical structural formula of the demethylated amide is described in the specification; and in the formulas, R1 is selected from aryl, alkyl and alkenyl groups, and R2 is selected from aryl, alkyl and alkenyl groups. With the method, N-demethylation of amide can be achieved; and the method has the advantages of mild reaction conditions, easiness in operation, low cost and the like.