72817-85-7

Basic information

• Product Name: Benzoic acid, 4-aMino-5-cyano-2-hydroxy-3-Methyl-, ethyl ester
• Synonyms: Benzoic acid, 4-aMino-5-cyano-2-hydroxy-3-Methyl-, ethyl ester;4-Amino-5-cyano-2-hydroxy-3-methyl-benzoic acid ethyl ester
• CAS NO: 72817-85-7
• Molecular Formula: C₁₁H₁₂N₂O₃
• Molecular Weight: 220.22458
• Mol File: 72817-85-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Benzoic acid, 4-aMino-5-cyano-2-hydroxy-3-Methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-aMino-5-cyano-2-hydroxy-3-Methyl-, ethyl ester(72817-85-7)
• EPA Substance Registry System: Benzoic acid, 4-aMino-5-cyano-2-hydroxy-3-Methyl-, ethyl ester(72817-85-7)

Safety Data

• Hazardous Substances Data: 72817-85-7(Hazardous Substances Data)

Upstream product

• 123-06-8 Ethoxymethylenemalononitrile 
• 4949-44-4 ethyl propanoylacetate 

Downstream Products

• 102569-26-6 2-amino-4-hydroxy-3-methylbenzonitrile 
• 923274-69-5 4-Isopropylthiazole-2-carboxylic acid (6-carbamoyl-3-methoxy-2-methyl-phenyl)-amide 
• 923275-17-6 2-chloro-4-hydroxy-7-methoxy-8-methylquinazoline 
• 922520-23-8 2-(4-fluoro-benzoylamino)-4-methoxy-3-methyl-benzoic acid 
• 922520-29-4 7-Methoxy-8-methyl-2-phenylquinazolin-4-ol 
• 922520-32-9 2-amino-4-methoxy-3-methyl-benzoic acid methyl ester 
• 922520-33-0 2-amino-4-methoxy-3-methyl benzamide 
• 72817-91-5 4-Amino-5-carbamoyl-3-methylsalicylsaeure-ethylester 
• 72817-88-0 4-Amino-6-hydroxy-5-methylisophthalsaeure 
• 72817-94-8 4-amino-5-cyano-2-hydroxy-3-methylbenzoic acid 

Relevant articles and documents

Macrocylic Inhibitors of Hepatitis C Virus

Compounds of the formula I: and N-oxides, salts, and stereoisomers thereof wherein A is OR1, NHS(═O)pR2; wherein; R1 is hydrogen, C1-C6alkyl, C0-C3alkylenecarbocyclyl, C0-C3alkylene-heterocyclyl;R2 is C1-C6alkyl, C0-C3alkylenecarbocyclyl, C0-C3alkyleneheterocyclyl;p is independently 1 or 2;n is 3, 4, 5 or 6; — denotes an optional double bond;L is N or CRz; Rz is H or forms a double bond with the asterisked carbon;Rq is H or when L is CRz, Rq can also be C1-C6alkyl;Rr is quinazolinyl, optionally substituted with one two or three substituents each independently selected from C1-C6 alkyl, C1-C6alkoxy, hydroxyl, halo, haloC1-C6alkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C1-C6alkyl-carbonylamino, C0-C3alkylenecarbocyclyl and C0-C3 alkyleneheterocyclyl;R5 is hydrogen, C1-C6alkyl, C1-C6alkoxyC1-C6alkyl or C3-C7cycloalkyl;R6 is hydrogen, C1-C6alkyl, C1-C6alkoxy, C0-C3alkylenecarbocyclyl, C0-C3alkylene-heterocyclyl, hydroxy, bromo, chloro or fluoro have utility in the treatment or prophylaxis of flaviviral infections such as HCV

MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS

Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is -OR7, -NH-SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy, or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents ; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.