72842-25-2Relevant academic research and scientific papers
METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE
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Paragraph 0182; 0183, (2019/01/04)
A method is provided to conveniently separate racemic (3R,4S)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carboxamide and (3S,4R)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carboxamide using selective crystallization with chiral carboxylic acids.
A D-P-methyl-dibenzoyl tartaric acid synthesis method (by machine translation)
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Paragraph 0034-0036, (2017/03/08)
The invention discloses a Di-p-toluoyl-D-tartaric acid synthetic method. D-Tartaric acid and p-toluoyl chloride are taken as raw materials, copper sulfate is taken as a catalyst, toluene is taken as a solution, Di-p-toluoyl-D-tartaric anhydride is obtained through a reaction, an equivalent amount of water is added, and the toluene is hydrolyzed to obtain Di-p-toluoyl-D-tartaric acid, wherein the toluene solution, and water and the toluene in the hydrolysis can be recycled. The method is simple in process, safe and easy to operate, the process yield reaches over 95 percent; and at the same time, the cost of the raw materials is low, a part of raw material can be recycled, the purity of a finished product is high, and an excellent chiral resolution performance is achieved.
Resolution of (+/-)-propranolol.
Yost,Holtzman
, p. 1181 - 1182 (2007/10/06)
Two improvements in propranolol resolution were developed. Both the (+)- and (-)-di-(p-toluoyl)tartaric acids were used as the resolving agents. This procedure reduced the number of crystallizations needed to obtain a pure product. Furthermore, synthesis of the resolving agent was improved.
