72846-63-0Relevant academic research and scientific papers
Synthesis method of 2-(4-ethoxyphenyl)-2-methyl propanol
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Paragraph 0026, (2021/05/01)
The invention discloses a synthetic method of 2-(4-ethoxyphenyl)-2-methyl propanol, and belongs to the technical field of organic synthesis. The method comprises the following steps: performing isobutyryl chloride Friedel-Crafts acylation by taking cheap phenethyl ether as a raw material and ionic liquid as a reaction solvent, extracting and separating methyl tert-butyl ether after reaction, washing and drying an ether phase, recovering the ether phase, distilling and purifying to obtain a product, adding tert-butyl ether, adding metered liquid bromine for bromination, washing after bromination, treating and crystallizing, adding petroleum ether, refluxing, dehydrating and condensing with neopentyl glycol under the catalytic action of p-toluenesulfonic acid to obtain a condensation compound; and carrying out high-temperature transposition on the condensation compound and a catalyst zinc salt in a solvent, directly hydrolyzing with an alkaline solution, and finally reducing under the action of sodium borohydride and aluminum trichloride to obtain the 2-(4-ethoxyphenyl)-2-methyl propanol. The method is high in yield, safe, environmentally friendly and easy to operate, a small amount of aluminum trichloride is supplemented into the ionic liquid and then reused, and neopentyl glycol regenerated through the hydrolysis reaction can also be recycled.
Importance of β Phenyl Group in Ipso Substitution of Arylvinyl Cations
Kitamura, Tsugio,Soda, Shin-ichi,Nakamura, Ichizo,Fukuda, Tetsuro,Taniguchi, Hiroshi
, p. 2195 - 2198 (2007/10/02)
Intramolecular and intermolecular ipso substitutions of arylvinyl cations, i.e., α-vinyl cations and α-(p-methoxyphenyl)vinyl cations, were studied with respect to the effect of the β substituent and phenyl group as the β substi
