72850-61-4

Basic information

• Product Name: 2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID
• Synonyms: 2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID;5-Thiazolecarboxylicacid, 2-chloro-4-(trifluoroMethyl)-
• CAS NO: 72850-61-4
• Molecular Formula: C₅HClF₃NO₂S
• Molecular Weight: 231.58
• EINECS: 1533716-785-6
• Mol File: 72850-61-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 131-135 °C(Solv: hexane (110-54-3); benzene (71-43-2))
• Boiling Point: 337.4±52.0 °C(Predicted)
• Appearance: /
• Density: 1.779±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.57±0.36(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID(72850-61-4)
• EPA Substance Registry System: 2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID(72850-61-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 72850-61-4(Hazardous Substances Data)

Usage

General Description

The chemical 2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID is a compound with the molecular formula C6H3ClF3NO2S. It is a chlorinated thiazole derivative that contains a trifluoromethyl group and a carboxylic acid functional group. 2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID has potential applications in the pharmaceutical and agrochemical industries, as it can be used as a building block in the synthesis of various biologically active compounds. Its unique structure and functional groups make it a versatile intermediate for the production of novel drug candidates and crop-protection agents. Additionally, it may also have potential uses as a research tool in chemical biology and medicinal chemistry.

Upstream product

• 72850-52-3 ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate 
• 72850-53-4 ethyl 2,3-dihydro-2-oxo-4-trifluoromethyl-5-thiazole-carboxylate 
• 344-72-9 ethyl 2-amino-4-(trifluoromethyl)-5-thiazole-carboxylate 

Downstream Products

• 72850-69-2 2-chloro-4-trifluoromethyl-thiazole-5-carboxylic acid phenyl ester 
• 72850-64-7 benzyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate 
• 72860-48-1 2-chloro-4-trifluoromethyl-thiazole-5-carboxylic acid 4-chloro-phenyl ester 
• 72850-71-6 Methyl-2-chlor-4-trifluormethyl-5-thiazolcarboxylat 
• 72850-88-5 Diethylamine Salt of 2-Chloro-4-Trifluoromethyl-5-Thiazolecarboxylic Acid 
• 72850-87-4 Isopropylamine Salt of 2-Chloro-4-Trifluoromethyl-5-Thiazolecarboxylic Acid 

Relevant articles and documents

Synthesis and Insecticidal Activity of Novel Thiazole Acrylonitrile Derivatives

A series of novel thiazole acrylonitrile derivatives was designed and synthesized utilizing NC-510 as a precursor. Their structures were characterized by NMR spectrometry, MS, and elemental analysis. The results of bioassay indicated that some of these ti

Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates

A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.

2,4-Disubstituted-5-thiazole-carboxylic acids and derivatives

2,4-Disubstituted-5-thiazolecarboxylic acids and derivatives thereof have been found to reduce herbicidal injury of corn, rice and sorghum plants due to the application thereto of acetamide herbicides.