72861-80-4Relevant academic research and scientific papers
Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity
Ragab, Mahmoud A.,Elagawany, Mohamed,Daabees, Hoda,Ahmed, Al-Shaimaa F.,Awad, Eman M.,Billon, Cyrielle,Elgendy, Bahaa,Abouzid, Khaled A.M.,Kassab, Shaymaa E.
, (2021/12/20)
Nuclear Estrogen receptors (ER) are cytoplasmic proteins; translocated to the nucleus to induce transcriptional signals after getting bound to the estrogen hormone. ER activation implicated in cancer cell proliferation of female reproductive organs. Thus,
Asymmetric Transfer Hydrogenation of Arylidene-Substituted Chromanones and Tetralones Catalyzed by Noyori-Ikariya Ru(II) Complexes: One-Pot Reduction of C═C and C═O bonds
Caleffi, Guilherme S.,Brum, Juliana De O. C.,Costa, Angela T.,Domingos, Jorge L. O.,Costa, Paulo R. R.
, p. 4849 - 4858 (2021/04/06)
3-Arylidenechroman-4-ones and 2-arylidene-1-tetralones are hydrogenated to cis-benzylic alcohols in dr's and er's up to 99:1 via a C═C and C═O one-pot reduction in the presence of 2-5 mol % Noyori-Ikariya-type RuII chiral complexes and HCO2Na as a hydroge
Claisen-Schmidt, aza-Michael, cyclization via cascade strategy toward microwave promoted synthesis of imidazo[2,1-b]quinazolines
Devi Priya, Duraipandi,Mohana Roopan, Selvaraj
, p. 1813 - 1834 (2020/05/25)
Imidazole blended quinazolines are having a wide run of potential applications in synthetic field. In this current investigation, we reported a modern synthesis with the help of non-conventional energy. Optimization parameters have been stabilized utilizi
6-methoxy-3,4-dihydronaphthalenone chalcone-like derivatives as potent tyrosinase inhibitors and radical scavengers
Ranjbar, Sara,Akbari, Abdolhossein,Edraki, Najmeh,Khoshneviszadeh, Mahsima,Hemmatian, Hajar,Firuzi, Omidreza,Khoshneviszadeh, Mehdi
, p. 1170 - 1179 (2018/11/01)
Background: Tyrosinase is a copper-containing enzyme that involves in melanine biosynthesis and fruits enzymatic browning pathways. Chemical inhibitors of tyrosinase could have potential applications in cosmetics, medicine and food industry. In this study
Studies in Antifertility Agents: Part XXVIII-1,2-trans-1-(p-(&β-Pyrrolidinoethoxy)phenyl)-2-substituted-benzyl-6-methoxy-1,2,3,4-tetrahydronaphthalenes
Tewari, S. C.,Rastogi, Shri Nivas
, p. 1060 - 1064 (2007/10/02)
Substituted 2-benzyl-6-methoxy-1-tetralones (8-10), obtained by catalytic hydrogenation of 2-arylidene-1-tetralones (5-7), on NaBH4 reduction give a mixture of 1,2-trans-/cis-isomers of 2-benzyl-1-tetralols (11-13).Ac2O-pyridine treatment of 11 furnishes
